University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Ophthalmology (Eye & Ear Hospital)
  • Ophthalmology (Eye & Ear Hospital) - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Ophthalmology (Eye & Ear Hospital)
  • Ophthalmology (Eye & Ear Hospital) - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study

    Thumbnail
    Download
    Published version (418.3Kb)

    Citations
    Scopus
    Web of Science
    Altmetric
    3
    3
    Author
    Han, X; Yang, T; Zhang, J; Yu, S; Guo, X; Yan, W; Hu, Y; He, M
    Date
    2018-05-01
    Source Title
    BMJ Open
    Publisher
    BMJ PUBLISHING GROUP
    University of Melbourne Author/s
    He, Mingguang; Yan, William
    Affiliation
    Ophthalmology (Eye & Ear Hospital)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Han, X., Yang, T., Zhang, J., Yu, S., Guo, X., Yan, W., Hu, Y. & He, M. (2018). Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study. BMJ OPEN, 8 (2), https://doi.org/10.1136/bmjopen-2017-019416.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256025
    DOI
    10.1136/bmjopen-2017-019416
    Abstract
    OBJECTIVES: To investigate the longitudinal changes in intraocular pressure (IOP) and its associations with refractive error and systemic determinants in a Chinese geriatric population. DESIGN: Prospective cohort study. SETTING: Guangzhou Government Servant Physical Check-up Center, Guangzhou, China. PARTICIPANTS: 4413 government employees aged no less than 40 years (41.9% female) attending annual physical and eye examinations were included in this study. The inclusion criterion was having attended the 2010 follow-up examination. The exclusion criteria include glaucoma or intraocular surgery history, IOP >21 mm Hg at any visit or without available IOP data at all visits from 2010 to 2014. PRIMARY AND SECONDARY OUTCOME MEASURES: The outcome measure was IOP at each follow-up visit from 2010 to 2014. Mixed-effect model was used to assess the relationship between longitudinal changes in IOP and potential risk factors. RESULTS: For the 2653 participants who had available IOP data at both the 2010 and 2014 follow-up visits, the average change in IOP was an increase of 0.43 (95% CI 0.36 to 0.50) mm Hg. For the whole study population and in the optimised mixed model, there was a non-linear increase of IOP with age (P<0.001), with greater changes in younger subjects and in women (P<0.001 and P=0.002, respectively). Elevations in systolic blood pressure, diastolic blood pressure, body mass index (BMI) and fasting plasma glucose (FPG), as well as a myopic shift (all with P<0.001), during the follow-up were associated with an increasing trend of IOP, while serum lipids were found to be not significantly associated. CONCLUSIONS: In this cohort of elderly Chinese adults, IOP increases non-linearly with ageing. People with increasing blood pressure, BMI, FPG and myopic progression are more likely to have IOP elevation over time.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Ophthalmology (Eye & Ear Hospital) - Research Publications [450]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors