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dc.contributor.authorHan, X
dc.contributor.authorYang, T
dc.contributor.authorZhang, J
dc.contributor.authorYu, S
dc.contributor.authorGuo, X
dc.contributor.authorYan, W
dc.contributor.authorHu, Y
dc.contributor.authorHe, M
dc.date.accessioned2020-12-18T04:02:34Z
dc.date.available2020-12-18T04:02:34Z
dc.date.issued2018-05-01
dc.identifierpii: bmjopen-2017-019416
dc.identifier.citationHan, X., Yang, T., Zhang, J., Yu, S., Guo, X., Yan, W., Hu, Y. & He, M. (2018). Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study. BMJ OPEN, 8 (2), https://doi.org/10.1136/bmjopen-2017-019416.
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/11343/256025
dc.description.abstractOBJECTIVES: To investigate the longitudinal changes in intraocular pressure (IOP) and its associations with refractive error and systemic determinants in a Chinese geriatric population. DESIGN: Prospective cohort study. SETTING: Guangzhou Government Servant Physical Check-up Center, Guangzhou, China. PARTICIPANTS: 4413 government employees aged no less than 40 years (41.9% female) attending annual physical and eye examinations were included in this study. The inclusion criterion was having attended the 2010 follow-up examination. The exclusion criteria include glaucoma or intraocular surgery history, IOP >21 mm Hg at any visit or without available IOP data at all visits from 2010 to 2014. PRIMARY AND SECONDARY OUTCOME MEASURES: The outcome measure was IOP at each follow-up visit from 2010 to 2014. Mixed-effect model was used to assess the relationship between longitudinal changes in IOP and potential risk factors. RESULTS: For the 2653 participants who had available IOP data at both the 2010 and 2014 follow-up visits, the average change in IOP was an increase of 0.43 (95% CI 0.36 to 0.50) mm Hg. For the whole study population and in the optimised mixed model, there was a non-linear increase of IOP with age (P<0.001), with greater changes in younger subjects and in women (P<0.001 and P=0.002, respectively). Elevations in systolic blood pressure, diastolic blood pressure, body mass index (BMI) and fasting plasma glucose (FPG), as well as a myopic shift (all with P<0.001), during the follow-up were associated with an increasing trend of IOP, while serum lipids were found to be not significantly associated. CONCLUSIONS: In this cohort of elderly Chinese adults, IOP increases non-linearly with ageing. People with increasing blood pressure, BMI, FPG and myopic progression are more likely to have IOP elevation over time.
dc.languageEnglish
dc.publisherBMJ PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleLongitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study
dc.typeJournal Article
dc.identifier.doi10.1136/bmjopen-2017-019416
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.source.titleBMJ Open
melbourne.source.volume8
melbourne.source.issue2
dc.rights.licenseCC BY-NC
melbourne.elementsid1306229
melbourne.contributor.authorHe, Mingguang
melbourne.contributor.authorYan, William
dc.identifier.eissn2044-6055
melbourne.accessrightsOpen Access


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