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dc.contributor.authorHan, X
dc.contributor.authorYang, T
dc.contributor.authorZhang, J
dc.contributor.authorYu, S
dc.contributor.authorGuo, X
dc.contributor.authorYan, W
dc.contributor.authorHu, Y
dc.contributor.authorHe, M
dc.date.accessioned2020-12-18T04:02:34Z
dc.date.available2020-12-18T04:02:34Z
dc.date.issued2018-05-01
dc.identifierpii: bmjopen-2017-019416
dc.identifier.citationHan, X., Yang, T., Zhang, J., Yu, S., Guo, X., Yan, W., Hu, Y. & He, M. (2018). Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study. BMJ OPEN, 8 (2), https://doi.org/10.1136/bmjopen-2017-019416.
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/11343/256025
dc.description.abstractOBJECTIVES: To investigate the longitudinal changes in intraocular pressure (IOP) and its associations with refractive error and systemic determinants in a Chinese geriatric population. DESIGN: Prospective cohort study. SETTING: Guangzhou Government Servant Physical Check-up Center, Guangzhou, China. PARTICIPANTS: 4413 government employees aged no less than 40 years (41.9% female) attending annual physical and eye examinations were included in this study. The inclusion criterion was having attended the 2010 follow-up examination. The exclusion criteria include glaucoma or intraocular surgery history, IOP >21 mm Hg at any visit or without available IOP data at all visits from 2010 to 2014. PRIMARY AND SECONDARY OUTCOME MEASURES: The outcome measure was IOP at each follow-up visit from 2010 to 2014. Mixed-effect model was used to assess the relationship between longitudinal changes in IOP and potential risk factors. RESULTS: For the 2653 participants who had available IOP data at both the 2010 and 2014 follow-up visits, the average change in IOP was an increase of 0.43 (95% CI 0.36 to 0.50) mm Hg. For the whole study population and in the optimised mixed model, there was a non-linear increase of IOP with age (P<0.001), with greater changes in younger subjects and in women (P<0.001 and P=0.002, respectively). Elevations in systolic blood pressure, diastolic blood pressure, body mass index (BMI) and fasting plasma glucose (FPG), as well as a myopic shift (all with P<0.001), during the follow-up were associated with an increasing trend of IOP, while serum lipids were found to be not significantly associated. CONCLUSIONS: In this cohort of elderly Chinese adults, IOP increases non-linearly with ageing. People with increasing blood pressure, BMI, FPG and myopic progression are more likely to have IOP elevation over time.
dc.languageEnglish
dc.publisherBMJ PUBLISHING GROUP
dc.titleLongitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study
dc.typeJournal Article
dc.identifier.doi10.1136/bmjopen-2017-019416
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.source.titleBMJ Open
melbourne.source.volume8
melbourne.source.issue2
dc.rights.licenseCC BY-NC
melbourne.elementsid1306229
melbourne.contributor.authorHe, Mingguang
melbourne.contributor.authorYan, William
dc.identifier.eissn2044-6055
melbourne.accessrightsOpen Access


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