University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Obstetrics and Gynaecology
  • Obstetrics and Gynaecology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

    Thumbnail
    Download
    Published version (1.084Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    12
    10
    Author
    Block, MS; Vierkant, RA; Rambau, PF; Winham, SJ; Wagner, P; Traficante, N; Toloczko, A; Tiezzi, DG; Taran, FA; Sinn, P; ...
    Date
    2018-03-01
    Source Title
    Mayo Clinic Proceedings
    Publisher
    ELSEVIER SCIENCE INC
    University of Melbourne Author/s
    Bowtell, David; Campbell, Ian
    Affiliation
    Obstetrics and Gynaecology
    Sir Peter MacCallum Department of Oncology
    Medicine and Radiology
    Clinical Pathology
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Block, M. S., Vierkant, R. A., Rambau, P. F., Winham, S. J., Wagner, P., Traficante, N., Toloczko, A., Tiezzi, D. G., Taran, F. A., Sinn, P., Sieh, W., Sharma, R., Rothstein, J. H., Ramon y Cajal, T., Paz-Ares, L., Oszurek, O., Orsulic, S., Ness, R. B., Nelson, G. ,... Goode, E. L. (2018). MyD88 and TLR4 Expression in Epithelial Ovarian Cancer. MAYO CLINIC PROCEEDINGS, 93 (3), pp.307-320. https://doi.org/10.1016/j.mayocp.2017.10.023.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256043
    DOI
    10.1016/j.mayocp.2017.10.023
    Abstract
    OBJECTIVE: To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. PATIENTS AND METHODS: We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). RESULTS: Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P<.001 for both). In HGSOC, strong MyD88 expression was modestly associated with shortened overall survival (hazard ratio [HR], 1.13; 95% CI, 1.01-1.26; P=.04) but was also associated with advanced stage (P<.001). The expression of TLR4 was not associated with survival. In low-grade serous ovarian cancer (LGSOC), strong expression of both MyD88 and TLR4 was associated with favorable survival (HR [95% CI], 0.49 [0.29-0.84] and 0.44 [0.21-0.89], respectively; P=.009 and P=.02, respectively). CONCLUSION: Results are consistent with an association between strong MyD88 staining and advanced stage and poorer survival in HGSOC and demonstrate correlation between strong MyD88 and TLR4 staining and improved survival in LGSOC, highlighting the biological differences between the 2 serous histotypes.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53102]
    • Melbourne School of Population and Global Health - Research Publications [5352]
    • Clinical Pathology - Research Publications [620]
    • Medicine and Radiology - Research Publications [3320]
    • Sir Peter MacCallum Department of Oncology - Research Publications [1023]
    • Obstetrics and Gynaecology - Research Publications [831]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors