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dc.contributor.authorBlock, MS
dc.contributor.authorVierkant, RA
dc.contributor.authorRambau, PF
dc.contributor.authorWinham, SJ
dc.contributor.authorWagner, P
dc.contributor.authorTraficante, N
dc.contributor.authorToloczko, A
dc.contributor.authorTiezzi, DG
dc.contributor.authorTaran, FA
dc.contributor.authorSinn, P
dc.contributor.authorSieh, W
dc.contributor.authorSharma, R
dc.contributor.authorRothstein, JH
dc.contributor.authorRamon y Cajal, T
dc.contributor.authorPaz-Ares, L
dc.contributor.authorOszurek, O
dc.contributor.authorOrsulic, S
dc.contributor.authorNess, RB
dc.contributor.authorNelson, G
dc.contributor.authorModugno, F
dc.contributor.authorMenkiszak, J
dc.contributor.authorMcGuire, V
dc.contributor.authorMcCauley, BM
dc.contributor.authorMack, M
dc.contributor.authorLubinski, J
dc.contributor.authorLongacre, TA
dc.contributor.authorLi, Z
dc.contributor.authorLester, J
dc.contributor.authorKennedy, CJ
dc.contributor.authorKalli, KR
dc.contributor.authorJung, AY
dc.contributor.authorJohnatty, SE
dc.contributor.authorJimenez-Linan, M
dc.contributor.authorJensen, A
dc.contributor.authorIntermaggio, MP
dc.contributor.authorHung, J
dc.contributor.authorHerpel, E
dc.contributor.authorHernandez, BY
dc.contributor.authorHartkopf, AD
dc.contributor.authorHarnett, PR
dc.contributor.authorGhatage, P
dc.contributor.authorGarcia-Bueno, JM
dc.contributor.authorGao, B
dc.contributor.authorFereday, S
dc.contributor.authorEilber, U
dc.contributor.authorEdwards, RP
dc.contributor.authorde Sousa, CB
dc.contributor.authorde Andrade, JM
dc.contributor.authorChudecka-Glaz, A
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorCazorla, A
dc.contributor.authorBrucker, SY
dc.contributor.authorAlsop, J
dc.contributor.authorWhittemore, AS
dc.contributor.authorSteed, H
dc.contributor.authorStaebler, A
dc.contributor.authorMoysich, KB
dc.contributor.authorMenon, U
dc.contributor.authorKoziak, JM
dc.contributor.authorKommoss, S
dc.contributor.authorKjaer, SK
dc.contributor.authorKelemen, LE
dc.contributor.authorKarlan, BY
dc.contributor.authorHuntsman, DG
dc.contributor.authorHogdall, E
dc.contributor.authorGronwald, J
dc.contributor.authorGoodman, MT
dc.contributor.authorGilks, B
dc.contributor.authorJose Garcia, M
dc.contributor.authorFasching, PA
dc.contributor.authorde Fazio, A
dc.contributor.authorDeen, S
dc.contributor.authorChang-Claude, J
dc.contributor.authordos Reis, FJC
dc.contributor.authorCampbell, IG
dc.contributor.authorBrenton, JD
dc.contributor.authorBowtell, DD
dc.contributor.authorBenitez, J
dc.contributor.authorPharoah, PDP
dc.contributor.authorKobel, M
dc.contributor.authorRamus, SJ
dc.contributor.authorGoode, EL
dc.date.accessioned2020-12-18T04:04:58Z
dc.date.available2020-12-18T04:04:58Z
dc.date.issued2018-03-01
dc.identifierpii: S0025-6196(17)30873-X
dc.identifier.citationBlock, M. S., Vierkant, R. A., Rambau, P. F., Winham, S. J., Wagner, P., Traficante, N., Toloczko, A., Tiezzi, D. G., Taran, F. A., Sinn, P., Sieh, W., Sharma, R., Rothstein, J. H., Ramon y Cajal, T., Paz-Ares, L., Oszurek, O., Orsulic, S., Ness, R. B., Nelson, G. ,... Goode, E. L. (2018). MyD88 and TLR4 Expression in Epithelial Ovarian Cancer. MAYO CLINIC PROCEEDINGS, 93 (3), pp.307-320. https://doi.org/10.1016/j.mayocp.2017.10.023.
dc.identifier.issn0025-6196
dc.identifier.urihttp://hdl.handle.net/11343/256043
dc.description.abstractOBJECTIVE: To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. PATIENTS AND METHODS: We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). RESULTS: Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P<.001 for both). In HGSOC, strong MyD88 expression was modestly associated with shortened overall survival (hazard ratio [HR], 1.13; 95% CI, 1.01-1.26; P=.04) but was also associated with advanced stage (P<.001). The expression of TLR4 was not associated with survival. In low-grade serous ovarian cancer (LGSOC), strong expression of both MyD88 and TLR4 was associated with favorable survival (HR [95% CI], 0.49 [0.29-0.84] and 0.44 [0.21-0.89], respectively; P=.009 and P=.02, respectively). CONCLUSION: Results are consistent with an association between strong MyD88 staining and advanced stage and poorer survival in HGSOC and demonstrate correlation between strong MyD88 and TLR4 staining and improved survival in LGSOC, highlighting the biological differences between the 2 serous histotypes.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE INC
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleMyD88 and TLR4 Expression in Epithelial Ovarian Cancer
dc.typeJournal Article
dc.identifier.doi10.1016/j.mayocp.2017.10.023
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentObstetrics and Gynaecology
melbourne.affiliation.departmentClinical Pathology
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleMayo Clinic Proceedings
melbourne.source.volume93
melbourne.source.issue3
melbourne.source.pages307-320
melbourne.identifier.nhmrc310670
melbourne.identifier.nhmrc400281
melbourne.identifier.nhmrc628903
melbourne.identifier.nhmrc400413
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1308744
melbourne.contributor.authorBowtell, David
melbourne.contributor.authorCampbell, Ian
dc.identifier.eissn1942-5546
melbourne.identifier.fundernameidNHMRC, 310670
melbourne.identifier.fundernameidUNITED STATES DEPT OF DEFENSE, OC000109
melbourne.identifier.fundernameidNHMRC, 400281
melbourne.identifier.fundernameidNHMRC, 628903
melbourne.identifier.fundernameidNHMRC, 400413
melbourne.accessrightsOpen Access


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