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dc.contributor.authorMoore, JWJ
dc.contributor.authorMoyo, D
dc.contributor.authorBeattie, L
dc.contributor.authorAndrews, PS
dc.contributor.authorTimmis, J
dc.contributor.authorKaye, PM
dc.date.accessioned2020-12-18T04:08:07Z
dc.date.available2020-12-18T04:08:07Z
dc.date.issued2013-01-01
dc.identifier.citationMoore, J. W. J., Moyo, D., Beattie, L., Andrews, P. S., Timmis, J. & Kaye, P. M. (2013). Functional complexity of the Leishmania granuloma and the potential of in silico modeling. FRONTIERS IN IMMUNOLOGY, 4 (FRB), https://doi.org/10.3389/fimmu.2013.00035.
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/11343/256065
dc.description.abstractIn human and canine visceral leishmaniasis and in various experimental models of this disease, host resistance is strongly linked to efficient granuloma development. However, it is unknown exactly how the granuloma microenvironment executes an effective antileishmanial response. Recent studies, including using advanced imaging techniques, have improved our understanding of granuloma biology at the cellular level, highlighting heterogeneity in granuloma development and function, and hinting at complex cellular, temporal, and spatial dynamics. In this mini-review, we discuss the factors involved in the formation and function of Leishmania donovani-induced hepatic granulomas, as well as their importance in protecting against inflammation-associated tissue damage and the generation of immunity to rechallenge. Finally, we discuss the role that computational, agent-based models may play in answering outstanding questions within the field.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.titleFunctional complexity of the Leishmania granuloma and the potential of in silico modeling
dc.typeJournal Article
dc.identifier.doi10.3389/fimmu.2013.00035
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleFrontiers in Immunology
melbourne.source.volume4
melbourne.source.issueFRB
dc.rights.licenseCC BY
melbourne.elementsid1312275
melbourne.contributor.authorBeattie, Lynette
dc.identifier.eissn1664-3224
melbourne.accessrightsOpen Access


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