Show simple item record

dc.contributor.authorSelby-Pham, SNB
dc.contributor.authorMiller, RB
dc.contributor.authorHowell, K
dc.contributor.authorDunshea, F
dc.contributor.authorBennett, LE
dc.date.accessioned2020-12-18T04:08:49Z
dc.date.available2020-12-18T04:08:49Z
dc.date.issued2017-05-16
dc.identifierpii: 10.1038/s41598-017-01888-w
dc.identifier.citationSelby-Pham, S. N. B., Miller, R. B., Howell, K., Dunshea, F. & Bennett, L. E. (2017). Physicochemical properties of dietary phytochemicals can predict their passive absorption in the human small intestine. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-01888-w.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/256070
dc.description.abstractA diet high in phytochemical-rich plant foods is associated with reducing the risk of chronic diseases such as cardiovascular and neurodegenerative diseases, obesity, diabetes and cancer. Oxidative stress and inflammation (OSI) is the common component underlying these chronic diseases. Whilst the positive health effects of phytochemicals and their metabolites have been demonstrated to regulate OSI, the timing and absorption for best effect is not well understood. We developed a model to predict the time to achieve maximal plasma concentration (Tmax) of phytochemicals in fruits and vegetables. We used a training dataset containing 67 dietary phytochemicals from 31 clinical studies to develop the model and validated the model using three independent datasets comprising a total of 108 dietary phytochemicals and 98 pharmaceutical compounds. The developed model based on dietary intake forms and the physicochemical properties lipophilicity and molecular mass accurately predicts Tmax of dietary phytochemicals and pharmaceutical compounds over a broad range of chemical classes. This is the first direct model to predict Tmax of dietary phytochemicals in the human body. The model informs the clinical dosing frequency for optimising uptake and sustained presence of dietary phytochemicals in circulation, to maximise their bio-efficacy for positively affect human health and managing OSI in chronic diseases.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titlePhysicochemical properties of dietary phytochemicals can predict their passive absorption in the human small intestine
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-017-01888-w
melbourne.affiliation.departmentAgriculture and Food Systems
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1210197
melbourne.contributor.authorDunshea, Frank
melbourne.contributor.authorSelby-Pham, Sophie Ngoc Bich
melbourne.contributor.authorHowell, Kate
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record