Show simple item record

dc.contributor.authorBrodie, EJ
dc.contributor.authorInfantino, S
dc.contributor.authorLow, MSY
dc.contributor.authorTarlinton, DM
dc.date.accessioned2020-12-18T04:10:17Z
dc.date.available2020-12-18T04:10:17Z
dc.date.issued2018-03-01
dc.identifier.citationBrodie, E. J., Infantino, S., Low, M. S. Y. & Tarlinton, D. M. (2018). Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in immunity. FRONTIERS IN IMMUNOLOGY, 9 (MAR), https://doi.org/10.3389/fimmu.2018.00401.
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/11343/256081
dc.description.abstractSystemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as such represent an attractive therapeutic target. Lyn is a Src family tyrosine kinase that plays a major role in regulating signaling pathways within B cells as well as other hematopoietic cells. Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn-/- mice developing an SLE-like disease with plasma cell hyperplasia, underscoring the importance of tightly regulating signaling within B cells. This review highlights recent advances in our understanding of the function of the Src family tyrosine kinase Lyn in B lymphocytes and its contribution to positive and negative signaling pathways that are dysregulated in autoimmunity.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleLyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in immunity
dc.typeJournal Article
dc.identifier.doi10.3389/fimmu.2018.00401
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleFrontiers in Immunology
melbourne.source.volume9
melbourne.source.issueMAR
dc.rights.licenseCC BY
melbourne.elementsid1312505
melbourne.contributor.authorInfantino, Simona
dc.identifier.eissn1664-3224
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record