Blood Pressure and Arterial Stiffness in Kenyan Adolescents With alpha(+)Thalassemia
AuthorEtyang, AO; Khayeka-Wandabwa, C; Kapesa, S; Muthumbi, E; Odipo, E; Wamukoya, M; Ngomi, N; Haregu, T; Kyobutungi, C; Tendwa, M; ...
Source TitleJournal of the American Heart Association
University of Melbourne Author/sHaregu, Tilahun
AffiliationMelbourne School of Population and Global Health
Document TypeJournal Article
CitationsEtyang, A. O., Khayeka-Wandabwa, C., Kapesa, S., Muthumbi, E., Odipo, E., Wamukoya, M., Ngomi, N., Haregu, T., Kyobutungi, C., Tendwa, M., Makale, J., Macharia, A., Cruickshank, J. K., Smeeth, L., Scott, J. A. G. & Williams, T. N. (2017). Blood Pressure and Arterial Stiffness in Kenyan Adolescents With alpha(+)Thalassemia. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6 (4), https://doi.org/10.1161/JAHA.117.005613.
Access StatusOpen Access
BACKGROUND: Recent studies have discovered that α-globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with α+thalassemia, in whom the production of α-globin is reduced. METHODS AND RESULTS: The study was conducted in Nairobi, Kenya, among 938 adolescents aged 11 to 17 years. Twenty-four-hour ambulatory BP monitoring and arterial stiffness measurements were performed using an arteriograph device. We genotyped for α+thalassemia by polymerase chain reaction. Complete data for analysis were available for 623 subjects; 223 (36%) were heterozygous (-α/αα) and 47 (8%) were homozygous (-α/-α) for α+thalassemia whereas the remaining 353 (55%) were normal (αα/αα). Mean 24-hour systolic BP ±SD was 118±12 mm Hg in αα/αα, 117±11 mm Hg in -α/αα, and 118±11 mm Hg in -α/-α subjects, respectively. Mean 24-hour diastolic BP ±SD in these groups was 64±8, 63±7, and 65±8 mm Hg, respectively. Mean pulse wave velocity (PWV)±SD was 7±0.8, 7±0.8, and 7±0.7 ms-1, respectively. No differences were observed in PWV and any of the 24-hour ambulatory BP monitoring-derived measures between those with and without α+thalassemia. CONCLUSIONS: These data suggest that the presence of α+thalassemia does not affect BP and/or arterial stiffness in Kenyan adolescents.
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