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    Bayesian statistical modelling of human protein interaction network incorporating protein disorder information.

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    Author
    Bulashevska, S; Bulashevska, A; Eils, R
    Date
    2010-01-25
    Source Title
    BMC Bioinformatics
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Kotagiri, Ramamohanarao
    Affiliation
    Computing and Information Systems
    Metadata
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    Document Type
    Journal Article
    Citations
    Bulashevska, S., Bulashevska, A. & Eils, R. (2010). Bayesian statistical modelling of human protein interaction network incorporating protein disorder information.. BMC Bioinformatics, 11 (1), pp.46-. https://doi.org/10.1186/1471-2105-11-46.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256095
    DOI
    10.1186/1471-2105-11-46
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831004
    Abstract
    BACKGROUND: We present a statistical method of analysis of biological networks based on the exponential random graph model, namely p2-model, as opposed to previous descriptive approaches. The model is capable to capture generic and structural properties of a network as emergent from local interdependencies and uses a limited number of parameters. Here, we consider one global parameter capturing the density of edges in the network, and local parameters representing each node's contribution to the formation of edges in the network. The modelling suggests a novel definition of important nodes in the network, namely social, as revealed based on the local sociality parameters of the model. Moreover, the sociality parameters help to reveal organizational principles of the network. An inherent advantage of our approach is the possibility of hypotheses testing: a priori knowledge about biological properties of the nodes can be incorporated into the statistical model to investigate its influence on the structure of the network. RESULTS: We applied the statistical modelling to the human protein interaction network obtained with Y2H experiments. Bayesian approach for the estimation of the parameters was employed. We deduced social proteins, essential for the formation of the network, while incorporating into the model information on protein disorder. Intrinsically disordered are proteins which lack a well-defined three-dimensional structure under physiological conditions. We predicted the fold group (ordered or disordered) of proteins in the network from their primary sequences. The network analysis indicated that protein disorder has a positive effect on the connectivity of proteins in the network, but do not fully explains the interactivity. CONCLUSIONS: The approach opens a perspective to study effects of biological properties of individual entities on the structure of biological networks.

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