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dc.contributor.authorMoore, JWJ
dc.contributor.authorBeattie, L
dc.contributor.authorOsman, M
dc.contributor.authorOwens, BMJ
dc.contributor.authorBrown, N
dc.contributor.authorDalton, JE
dc.contributor.authorMaroof, A
dc.contributor.authorKaye, PM
dc.date.accessioned2020-12-18T04:13:34Z
dc.date.available2020-12-18T04:13:34Z
dc.date.issued2016-09-22
dc.identifierpii: PONE-D-16-18737
dc.identifier.citationMoore, J. W. J., Beattie, L., Osman, M., Owens, B. M. J., Brown, N., Dalton, J. E., Maroof, A. & Kaye, P. M. (2016). CD4(+) Recent Thymic Emigrants Are Recruited into Granulomas during Leishmania donovani Infection but Have Limited Capacity for Cytokine Production. PLOS ONE, 11 (9), https://doi.org/10.1371/journal.pone.0163604.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/256104
dc.description.abstractRecent thymic emigrants (RTEs) represent a source of antigen-naïve T cells that enter the periphery throughout life. However, whether RTEs contribute to the control of chronic parasitic infection and how their potential might be harnessed by therapeutic intervention is currently unclear. Here, we show that CD4+ recent thymic emigrants emerging into the periphery of mice with ongoing Leishmania donovani infection undergo partial activation and are recruited to sites of granulomatous inflammation. However, CD4+ RTEs displayed severely restricted differentiation either into IFNγ+ or IFNγ+TNFα+ effectors, or into IL-10-producing regulatory T cells. Effector cell differentiation in the chronically infected host was not promoted by adoptive transfer of activated dendritic cells or by allowing extended periods of post-thymic differentiation in the periphery. Nevertheless, CD4+ RTEs from infected mice retained the capacity to transfer protection into lymphopenic RAG2-/- mice. Taken together, our data indicate that RTEs emerging into a chronically inflamed environment are not recruited into the effector pool, but retain the capacity for subsequent differentiation into host protective T cells when placed in a disease-free environment.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.titleCD4(+) Recent Thymic Emigrants Are Recruited into Granulomas during Leishmania donovani Infection but Have Limited Capacity for Cytokine Production
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0163604
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titlePLoS One
melbourne.source.volume11
melbourne.source.issue9
dc.rights.licenseCC BY
melbourne.elementsid1312268
melbourne.contributor.authorBeattie, Lynette
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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