Oxygen-permeable microwell device maintains islet mass and integrity during shipping
AuthorRojas-Canales, DM; Waibel, M; Forget, A; Penko, D; Nitschke, J; Harding, FJ; Delalat, B; Blencowe, A; Loudovaris, T; Grey, ST; ...
Source TitleEndocrine Connections
AffiliationMedicine and Radiology
Document TypeJournal Article
CitationsRojas-Canales, D. M., Waibel, M., Forget, A., Penko, D., Nitschke, J., Harding, F. J., Delalat, B., Blencowe, A., Loudovaris, T., Grey, S. T., Thomas, H. E., Kay, T. W. H., Drogemuller, C. J., Voelcker, N. H. & Coates, P. T. (2018). Oxygen-permeable microwell device maintains islet mass and integrity during shipping. ENDOCRINE CONNECTIONS, 7 (3), pp.490-503. https://doi.org/10.1530/EC-17-0349.
Access StatusOpen Access
Islet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islets are still lost in the pre-transplant period, limiting the success of this treatment. Moreover, current practice includes islets being prepared at specialized centers, which are sometimes remote to the transplant location. Thus, a critical point of intervention to maintain the quality and quantity of isolated islets is during transportation between isolation centers and the transplanting hospitals, during which 20-40% of functional islets can be lost. The current study investigated the use of an oxygen-permeable PDMS microwell device for long-distance transportation of isolated islets. We demonstrate that the microwell device protected islets from aggregation during transport, maintaining viability and average islet size during shipping.
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