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dc.contributor.authorRojas-Canales, DM
dc.contributor.authorWaibel, M
dc.contributor.authorForget, A
dc.contributor.authorPenko, D
dc.contributor.authorNitschke, J
dc.contributor.authorHarding, FJ
dc.contributor.authorDelalat, B
dc.contributor.authorBlencowe, A
dc.contributor.authorLoudovaris, T
dc.contributor.authorGrey, ST
dc.contributor.authorThomas, HE
dc.contributor.authorKay, TWH
dc.contributor.authorDrogemuller, CJ
dc.contributor.authorVoelcker, NH
dc.contributor.authorCoates, PT
dc.date.accessioned2020-12-18T04:15:32Z
dc.date.available2020-12-18T04:15:32Z
dc.date.issued2018-03-01
dc.identifierpii: EC-17-0349
dc.identifier.citationRojas-Canales, D. M., Waibel, M., Forget, A., Penko, D., Nitschke, J., Harding, F. J., Delalat, B., Blencowe, A., Loudovaris, T., Grey, S. T., Thomas, H. E., Kay, T. W. H., Drogemuller, C. J., Voelcker, N. H. & Coates, P. T. (2018). Oxygen-permeable microwell device maintains islet mass and integrity during shipping. ENDOCRINE CONNECTIONS, 7 (3), pp.490-503. https://doi.org/10.1530/EC-17-0349.
dc.identifier.issn2049-3614
dc.identifier.urihttp://hdl.handle.net/11343/256117
dc.description.abstractIslet transplantation is currently the only minimally invasive therapy available for patients with type 1 diabetes that can lead to insulin independence; however, it is limited to only a small number of patients. Although clinical procedures have improved in the isolation and culture of islets, a large number of islets are still lost in the pre-transplant period, limiting the success of this treatment. Moreover, current practice includes islets being prepared at specialized centers, which are sometimes remote to the transplant location. Thus, a critical point of intervention to maintain the quality and quantity of isolated islets is during transportation between isolation centers and the transplanting hospitals, during which 20-40% of functional islets can be lost. The current study investigated the use of an oxygen-permeable PDMS microwell device for long-distance transportation of isolated islets. We demonstrate that the microwell device protected islets from aggregation during transport, maintaining viability and average islet size during shipping.
dc.languageEnglish
dc.publisherBIOSCIENTIFICA LTD
dc.titleOxygen-permeable microwell device maintains islet mass and integrity during shipping
dc.typeJournal Article
dc.identifier.doi10.1530/EC-17-0349
melbourne.affiliation.departmentMedicine and Radiology
melbourne.source.titleEndocrine Connections
melbourne.source.volume7
melbourne.source.issue3
melbourne.source.pages490-503
dc.rights.licenseCC BY
melbourne.elementsid1313404
melbourne.contributor.authorKay, Thomas
melbourne.contributor.authorThomas, Helen
dc.identifier.eissn2049-3614
melbourne.accessrightsOpen Access


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