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dc.contributor.authorWong, ES
dc.contributor.authorYoung, LJ
dc.contributor.authorPapenfuss, AT
dc.contributor.authorBelov, K
dc.date.accessioned2020-12-18T04:16:47Z
dc.date.available2020-12-18T04:16:47Z
dc.date.issued2006-11-10
dc.identifierpii: 1745-7580-2-4
dc.identifier.citationWong, E. S., Young, L. J., Papenfuss, A. T. & Belov, K. (2006). In silico identification of opossum cytokine genes suggests the complexity of the marsupial immune system rivals that of eutherian mammals.. Immunome Res, 2 (1), pp.4-. https://doi.org/10.1186/1745-7580-2-4.
dc.identifier.issn1745-7580
dc.identifier.urihttp://hdl.handle.net/11343/256126
dc.description.abstractBACKGROUND: Cytokines are small proteins that regulate immunity in vertebrate species. Marsupial and eutherian mammals last shared a common ancestor more than 180 million years ago, so it is not surprising that attempts to isolate many key marsupial cytokines using traditional laboratory techniques have been unsuccessful. This paucity of molecular data has led some authors to suggest that the marsupial immune system is 'primitive' and not on par with the sophisticated immune system of eutherian (placental) mammals. RESULTS: The sequencing of the first marsupial genome has allowed us to identify highly divergent immune genes. We used gene prediction methods that incorporate the identification of gene location using BLAST, SYNTENY + BLAST and HMMER to identify 23 key marsupial immune genes, including IFN-gamma, IL-2, IL-4, IL-6, IL-12 and IL-13, in the genome of the grey short-tailed opossum (Monodelphis domestica). Many of these genes were not predicted in the publicly available automated annotations. CONCLUSION: The power of this approach was demonstrated by the identification of orthologous cytokines between marsupials and eutherians that share only 30% identity at the amino acid level. Furthermore, the presence of key immunological genes suggests that marsupials do indeed possess a sophisticated immune system, whose function may parallel that of eutherian mammals.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleIn silico identification of opossum cytokine genes suggests the complexity of the marsupial immune system rivals that of eutherian mammals.
dc.typeJournal Article
dc.identifier.doi10.1186/1745-7580-2-4
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleImmunome Research
melbourne.source.volume2
melbourne.source.issue1
melbourne.source.pages4-
dc.rights.licenseCC BY
melbourne.elementsid1313938
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1660534
melbourne.contributor.authorPapenfuss, Anthony
dc.identifier.eissn1745-7580
melbourne.accessrightsOpen Access


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