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dc.contributor.authorGanella, DE
dc.contributor.authorLee-Kardashyan, L
dc.contributor.authorLuikinga, SJ
dc.contributor.authorNguyen, DLD
dc.contributor.authorMadsen, HB
dc.contributor.authorZbukvic, IC
dc.contributor.authorCoulthard, R
dc.contributor.authorLawrence, AJ
dc.contributor.authorKim, JH
dc.date.accessioned2020-12-18T04:17:41Z
dc.date.available2020-12-18T04:17:41Z
dc.date.issued2017-05-09
dc.identifier.citationGanella, D. E., Lee-Kardashyan, L., Luikinga, S. J., Nguyen, D. L. D., Madsen, H. B., Zbukvic, I. C., Coulthard, R., Lawrence, A. J. & Kim, J. H. (2017). Aripiprazole Facilitates Extinction of Conditioned Fear in Adolescent Rats. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 11, https://doi.org/10.3389/fnbeh.2017.00076.
dc.identifier.issn1662-5153
dc.identifier.urihttp://hdl.handle.net/11343/256132
dc.description.abstractAnxiety disorders are the most common type of mental disorder during adolescence, which is at least partly due to the resistance to extinction exhibited at this age. The dopaminergic system is known to be dysregulated during adolescence; therefore, we aimed to facilitate extinction in adolescent rats using the dopamine receptor 2 partial agonist aripiprazole (Abilify™), and examine the behavioral and neural outcomes. Adolescent rats were conditioned to fear a tone. The next day, rats received extinction 30 min after a systemic injection of either 5 mg/kg aripiprazole or vehicle, and then were tested the following day. For the immunohistochemistry experiment, naïve and "no extinction" conditions were added and rats were perfused either on the extinction day or test day. To assess the activation of neurons receiving dopaminergic input, c-Fos, and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) labeled neurons were quantified in the amygdala and the medial prefrontal cortex (mPFC). Systemic treatment with aripiprazole at the time of extinction significantly reduced freezing at test the next day. This effect was not observed in rats that were fear conditioned but did not receive any extinction. Aripiprazole's facilitation of extinction was accompanied by increased activation of neurons in the mPFC. Taken together, aripiprazole represents a novel pharmacological adjunct to exposure therapy worthy of further examination. The effect of aripiprazole is related to enhanced activation of mPFC neurons receiving dopaminergic innervation.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAripiprazole Facilitates Extinction of Conditioned Fear in Adolescent Rats
dc.typeJournal Article
dc.identifier.doi10.3389/fnbeh.2017.00076
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.source.titleFrontiers in Behavioral Neuroscience
melbourne.source.volume11
melbourne.identifier.nhmrc1063140
melbourne.identifier.nhmrc1020737
melbourne.identifier.nhmrc1083309
melbourne.identifier.arcDP150102496
dc.rights.licenseCC BY
melbourne.elementsid1213381
melbourne.contributor.authorMadsen, Heather
melbourne.contributor.authorLuikinga, Sophia
melbourne.contributor.authorLawrence, Andrew
melbourne.contributor.authorGanella, Despina
melbourne.contributor.authorKim, Jee Hyun
melbourne.contributor.authorZbukvic, Isabel
dc.identifier.eissn1662-5153
melbourne.identifier.fundernameidNHMRC, 1063140
melbourne.identifier.fundernameidNHMRC, 1020737
melbourne.identifier.fundernameidNHMRC, 1083309
melbourne.identifier.fundernameidAustralian Research Council, DP150102496
melbourne.accessrightsOpen Access


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