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dc.contributor.authorSharp, JA
dc.contributor.authorLefevre, C
dc.contributor.authorNicholas, KR
dc.date.accessioned2020-12-18T04:19:53Z
dc.date.available2020-12-18T04:19:53Z
dc.date.issued2008-11-06
dc.identifierpii: 1741-7007-6-48
dc.identifier.citationSharp, J. A., Lefevre, C. & Nicholas, K. R. (2008). Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution. BMC BIOLOGY, 6 (1), https://doi.org/10.1186/1741-7007-6-48.
dc.identifier.issn1741-7007
dc.identifier.urihttp://hdl.handle.net/11343/256148
dc.description.abstractBACKGROUND: The mammary gland undergoes a sophisticated programme of developmental changes during pregnancy/lactation. However, little is known about processes involving initiation of apoptosis at involution following weaning. We used fur seals as models to study the molecular process of involution as these animals display a unique mammary gland phenotype. Fur seals have long lactation periods whereby mothers cycle between secreting copious quantities of milk for 2 to 3 days suckling pups on land, with trips to sea alone to forage for up to 23 days during which time mammary glands remain active without initiating apoptosis/involution. RESULTS: We show the molecular basis by which alpha-lactalbumin (LALBA), a secreted milk protein, is absent in Cape fur seals and demonstrate an apoptotic function for LALBA when exposed to mammary cells. CONCLUSION: We propose that apoptosis does not occur in fur seal mammary glands due to lack of LALBA in fur seal milk, allowing evasion of involution during a foraging trip. Our work identifies LALBA as a milk factor that feeds back on the mammary gland to regulate involution.
dc.languageEnglish
dc.publisherBMC
dc.titleLack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution
dc.typeJournal Article
dc.identifier.doi10.1186/1741-7007-6-48
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleBMC Biology
melbourne.source.volume6
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1315744
melbourne.contributor.authorLefevre, Christophe
dc.identifier.eissn1741-7007
melbourne.accessrightsOpen Access


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