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    Factors that influence adult neurogenesis as potential therapy

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    Author
    Shohayeb, B; Diab, M; Ahmed, M; Dominic, CHN
    Date
    2018-02-21
    Source Title
    Translational Neurodegeneration
    Publisher
    BMC
    University of Melbourne Author/s
    Ng, Dominic
    Affiliation
    Biochemistry and Molecular Biology
    Metadata
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    Document Type
    Journal Article
    Citations
    Shohayeb, B., Diab, M., Ahmed, M. & Dominic, C. H. N. (2018). Factors that influence adult neurogenesis as potential therapy. TRANSLATIONAL NEURODEGENERATION, 7 (1), https://doi.org/10.1186/s40035-018-0109-9.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256154
    DOI
    10.1186/s40035-018-0109-9
    Abstract
    Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain. The potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative disorders. In addition, adult neurogenesis might also play a role in mood and affective disorders. The factors that regulate adult neurogenesis have been broadly studied. However, the underlying molecular mechanisms of regulating neurogenesis are still not fully defined. In this review, we will provide critical analysis of our current understanding of the factors and molecular mechanisms that determine neurogenesis. We will further discuss pre-clinical and clinical studies that have investigated the potential of modulating neurogenesis as therapeutic intervention in neurodegeneration.

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