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dc.contributor.authorShohayeb, B
dc.contributor.authorDiab, M
dc.contributor.authorAhmed, M
dc.contributor.authorDominic, CHN
dc.date.accessioned2020-12-18T04:20:48Z
dc.date.available2020-12-18T04:20:48Z
dc.date.issued2018-02-21
dc.identifierpii: 109
dc.identifier.citationShohayeb, B., Diab, M., Ahmed, M. & Dominic, C. H. N. (2018). Factors that influence adult neurogenesis as potential therapy. TRANSLATIONAL NEURODEGENERATION, 7 (1), https://doi.org/10.1186/s40035-018-0109-9.
dc.identifier.issn2047-9158
dc.identifier.urihttp://hdl.handle.net/11343/256154
dc.description.abstractAdult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain. The potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative disorders. In addition, adult neurogenesis might also play a role in mood and affective disorders. The factors that regulate adult neurogenesis have been broadly studied. However, the underlying molecular mechanisms of regulating neurogenesis are still not fully defined. In this review, we will provide critical analysis of our current understanding of the factors and molecular mechanisms that determine neurogenesis. We will further discuss pre-clinical and clinical studies that have investigated the potential of modulating neurogenesis as therapeutic intervention in neurodegeneration.
dc.languageEnglish
dc.publisherBMC
dc.titleFactors that influence adult neurogenesis as potential therapy
dc.typeJournal Article
dc.identifier.doi10.1186/s40035-018-0109-9
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.source.titleTranslational Neurodegeneration
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1316353
melbourne.contributor.authorNg, Dominic
dc.identifier.eissn2047-9158
melbourne.accessrightsOpen Access


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