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dc.contributor.authorLi, S
dc.contributor.authorWong, EM
dc.contributor.authorDugue, P-A
dc.contributor.authorMcRae, AF
dc.contributor.authorKim, E
dc.contributor.authorJoo, J-HE
dc.contributor.authorNguyen, TL
dc.contributor.authorStone, J
dc.contributor.authorDite, GS
dc.contributor.authorArmstrong, NJ
dc.contributor.authorMather, KA
dc.contributor.authorThalamuthu, A
dc.contributor.authorWright, MJ
dc.contributor.authorAmes, D
dc.contributor.authorMilne, RL
dc.contributor.authorCraig, JM
dc.contributor.authorSaffery, R
dc.contributor.authorMontgomery, GW
dc.contributor.authorSong, Y-M
dc.contributor.authorSung, J
dc.contributor.authorSpector, TD
dc.contributor.authorSachdev, PS
dc.contributor.authorGiles, GG
dc.contributor.authorSouthey, MC
dc.contributor.authorHopper, JL
dc.date.accessioned2020-12-18T04:22:14Z
dc.date.available2020-12-18T04:22:14Z
dc.date.issued2018-06-01
dc.identifierpii: 4922690
dc.identifier.citationLi, S., Wong, E. M., Dugue, P. -A., McRae, A. F., Kim, E., Joo, J. -H. E., Nguyen, T. L., Stone, J., Dite, G. S., Armstrong, N. J., Mather, K. A., Thalamuthu, A., Wright, M. J., Ames, D., Milne, R. L., Craig, J. M., Saffery, R., Montgomery, G. W., Song, Y. -M. ,... Hopper, J. L. (2018). Genome-wide average DNA methylation is determined in utero. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 47 (3), pp.908-916. https://doi.org/10.1093/ije/dyy028.
dc.identifier.issn0300-5771
dc.identifier.urihttp://hdl.handle.net/11343/256165
dc.description.abstractBACKGROUND: Investigating the genetic and environmental causes of variation in genome-wide average DNA methylation (GWAM), a global methylation measure from the HumanMethylation450 array, might give a better understanding of genetic and environmental influences on methylation. METHODS: We measured GWAM for 2299 individuals aged 0 to 90 years from seven twin and/or family studies. We estimated familial correlations, modelled correlations with cohabitation history and fitted variance components models for GWAM. RESULTS: The correlation in GWAM for twin pairs was ∼0.8 at birth, decreased with age during adolescence and was constant at ∼0.4 throughout adulthood, with no evidence that twin pair correlations differed by zygosity. Non-twin first-degree relatives were correlated, from 0.17 [95% confidence interval (CI): 0.05-0.30] to 0.28 (95% CI: 0.08-0.48), except for middle-aged siblings (0.01, 95% CI: -0.10-0.12), and the correlation increased with time living together and decreased with time living apart. Spouse pairs were correlated in all studies, from 0.23 (95% CI: 0.3-0.43) to 0.31 (95% CI: 0.05-0.52), and the correlation increased with time living together. The variance explained by environmental factors shared by twins alone was 90% (95% CI: 74-95%) at birth, decreased in early life and plateaued at 28% (95% CI: 17-39%) in middle age and beyond. There was a cohabitation-related environmental component of variance. CONCLUSIONS: GWAM is determined in utero by prenatal environmental factors, the effects of which persist throughout life. The variation of GWAM is also influenced by environmental factors shared by family members, as well as by individual-specific environmental factors.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS
dc.titleGenome-wide average DNA methylation is determined in utero
dc.typeJournal Article
dc.identifier.doi10.1093/ije/dyy028
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentClinical Pathology
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleInternational Journal of Epidemiology
melbourne.source.volume47
melbourne.source.issue3
melbourne.source.pages908-916
melbourne.identifier.nhmrc1079102
dc.rights.licenseCC BY-NC
melbourne.elementsid1312774
melbourne.contributor.authorAmes, David
melbourne.contributor.authorSouthey, Melissa
melbourne.contributor.authorMilne, Roger
melbourne.contributor.authorLi, Shuai
melbourne.contributor.authorJoo, Ji Hoon
melbourne.contributor.authorNguyen, Tuong
melbourne.contributor.authorDugue, Pierre-Antoine
melbourne.contributor.authorSaffery, Richard
melbourne.contributor.authorWong, Ee Ming
melbourne.contributor.authorCraig, Jeffrey
melbourne.contributor.authorHopper, John
melbourne.contributor.authorDite, Gillian
melbourne.contributor.authorGiles, Graham
dc.identifier.eissn1464-3685
melbourne.identifier.fundernameidNHMRC, 1079102
melbourne.accessrightsOpen Access


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