Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain
Web of Science
AuthorSimpson, T; Pase, M; Stough, C
Source TitleEvidence-Based Complementary and Alternative Medicine
University of Melbourne Author/sPase, Matthew
AffiliationFlorey Department of Neuroscience and Mental Health
Document TypeJournal Article
CitationsSimpson, T., Pase, M. & Stough, C. (2015). Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, https://doi.org/10.1155/2015/615384.
Access StatusOpen Access
The detrimental effect of neuronal cell death due to oxidative stress and mitochondrial dysfunction has been implicated in age-related cognitive decline and neurodegenerative disorders such as Alzheimer's disease. The Indian herb Bacopa monnieri is a dietary antioxidant, with animal and in vitro studies indicating several modes of action that may protect the brain against oxidative damage. In parallel, several studies using the CDRI08 extract have shown that extracts of Bacopa monnieri improve cognitive function in humans. The biological mechanisms of this cognitive enhancement are unknown. In this review we discuss the animal studies and in vivo evidence for Bacopa monnieri as a potential therapeutic antioxidant to reduce oxidative stress and improve cognitive function. We suggest that future studies incorporate neuroimaging particularly magnetic resonance spectroscopy into their randomized controlled trials to better understand whether changes in antioxidant status in vivo cause improvements in cognitive function.
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