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    Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis.

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    Author
    Shalapour, S; Deiser, K; Kühl, AA; Glauben, R; Krug, SM; Fischer, A; Sercan, O; Chappaz, S; Bereswill, S; Heimesaat, MM; ...
    Date
    2012
    Source Title
    PLoS One
    Publisher
    Public Library of Science (PLoS)
    University of Melbourne Author/s
    Chappaz, Stephanie
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Shalapour, S., Deiser, K., Kühl, A. A., Glauben, R., Krug, S. M., Fischer, A., Sercan, O., Chappaz, S., Bereswill, S., Heimesaat, M. M., Loddenkemper, C., Fromm, M., Finke, D., Hämmerling, G. J., Arnold, B., Siegmund, B. & Schüler, T. (2012). Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis.. PLoS One, 7 (2), pp.e31939-. https://doi.org/10.1371/journal.pone.0031939.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256228
    DOI
    10.1371/journal.pone.0031939
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288069
    Abstract
    Interleukin-7 (IL-7) is a major survival factor for mature T cells. Therefore, the degree of IL-7 availability determines the size of the peripheral T cell pool and regulates T cell homeostasis. Here we provide evidence that IL-7 also regulates the homeostasis of intestinal epithelial cells (IEC), colon function and the composition of the commensal microflora. In the colon of T cell-deficient, lymphopenic mice, IL-7-producing IEC accumulate. IEC hyperplasia can be blocked by IL-7-consuming T cells or the inactivation of the IL-7/IL-7R signaling pathway. However, the blockade of the IL-7/IL-7R signaling pathway renders T cell-deficient mice more sensitive to chemically-induced IEC damage and subsequent colitis. In summary, our data demonstrate that IL-7 promotes IEC hyperplasia under lymphopenic conditions. Under non-lymphopenic conditions, however, T cells consume IL-7 thereby limiting IEC expansion and survival. Hence, the degree of IL-7 availability regulates both, T cell and IEC homeostasis.

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