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dc.contributor.authorShalapour, S
dc.contributor.authorDeiser, K
dc.contributor.authorKühl, AA
dc.contributor.authorGlauben, R
dc.contributor.authorKrug, SM
dc.contributor.authorFischer, A
dc.contributor.authorSercan, O
dc.contributor.authorChappaz, S
dc.contributor.authorBereswill, S
dc.contributor.authorHeimesaat, MM
dc.contributor.authorLoddenkemper, C
dc.contributor.authorFromm, M
dc.contributor.authorFinke, D
dc.contributor.authorHämmerling, GJ
dc.contributor.authorArnold, B
dc.contributor.authorSiegmund, B
dc.contributor.authorSchüler, T
dc.date.accessioned2020-12-18T04:31:01Z
dc.date.available2020-12-18T04:31:01Z
dc.date.issued2012
dc.identifierpii: PONE-D-11-17214
dc.identifier.citationShalapour, S., Deiser, K., Kühl, A. A., Glauben, R., Krug, S. M., Fischer, A., Sercan, O., Chappaz, S., Bereswill, S., Heimesaat, M. M., Loddenkemper, C., Fromm, M., Finke, D., Hämmerling, G. J., Arnold, B., Siegmund, B. & Schüler, T. (2012). Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis.. PLoS One, 7 (2), pp.e31939-. https://doi.org/10.1371/journal.pone.0031939.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/256228
dc.description.abstractInterleukin-7 (IL-7) is a major survival factor for mature T cells. Therefore, the degree of IL-7 availability determines the size of the peripheral T cell pool and regulates T cell homeostasis. Here we provide evidence that IL-7 also regulates the homeostasis of intestinal epithelial cells (IEC), colon function and the composition of the commensal microflora. In the colon of T cell-deficient, lymphopenic mice, IL-7-producing IEC accumulate. IEC hyperplasia can be blocked by IL-7-consuming T cells or the inactivation of the IL-7/IL-7R signaling pathway. However, the blockade of the IL-7/IL-7R signaling pathway renders T cell-deficient mice more sensitive to chemically-induced IEC damage and subsequent colitis. In summary, our data demonstrate that IL-7 promotes IEC hyperplasia under lymphopenic conditions. Under non-lymphopenic conditions, however, T cells consume IL-7 thereby limiting IEC expansion and survival. Hence, the degree of IL-7 availability regulates both, T cell and IEC homeostasis.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleInterleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis.
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0031939
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titlePLoS One
melbourne.source.volume7
melbourne.source.issue2
melbourne.source.pagese31939-
dc.rights.licenseCC BY
melbourne.elementsid1317181
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288069
melbourne.contributor.authorChappaz, Stephanie
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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