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dc.contributor.authorDixon-Suen, SC
dc.contributor.authorNagle, CM
dc.contributor.authorThrift, AP
dc.contributor.authorPharoah, PDP
dc.contributor.authorEwing, A
dc.contributor.authorPearce, CL
dc.contributor.authorZheng, W
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorFasching, PA
dc.contributor.authorBeckmann, MW
dc.contributor.authorLambrechts, D
dc.contributor.authorVergote, I
dc.contributor.authorLambrechts, S
dc.contributor.authorVan Nieuwenhuysen, E
dc.contributor.authorRossing, MA
dc.contributor.authorDoherty, JA
dc.contributor.authorWicklund, KG
dc.contributor.authorChang-Claude, J
dc.contributor.authorJung, AY
dc.contributor.authorMoysich, KB
dc.contributor.authorOdunsi, K
dc.contributor.authorGoodman, MT
dc.contributor.authorWilkens, LR
dc.contributor.authorThompson, PJ
dc.contributor.authorShvetsov, YB
dc.contributor.authorDoerk, T
dc.contributor.authorPark-Simon, T-W
dc.contributor.authorHillemanns, P
dc.contributor.authorBogdanova, N
dc.contributor.authorButzow, R
dc.contributor.authorNevanlinna, H
dc.contributor.authorPelttari, LM
dc.contributor.authorLeminen, A
dc.contributor.authorModugno, F
dc.contributor.authorNess, RB
dc.contributor.authorEdwards, RP
dc.contributor.authorKelley, JL
dc.contributor.authorHeitz, F
dc.contributor.authordu Bois, A
dc.contributor.authorHarter, P
dc.contributor.authorSchwaab, I
dc.contributor.authorKarlan, BY
dc.contributor.authorLester, J
dc.contributor.authorOrsulic, S
dc.contributor.authorRimel, BJ
dc.contributor.authorKjaer, SK
dc.contributor.authorHogdall, E
dc.contributor.authorJensen, A
dc.contributor.authorGoode, EL
dc.contributor.authorFridley, BL
dc.contributor.authorCunningham, JM
dc.contributor.authorWinham, SJ
dc.contributor.authorGiles, GG
dc.contributor.authorBruinsma, F
dc.contributor.authorMilne, RL
dc.contributor.authorSouthey, MC
dc.contributor.authorHildebrandt, MAT
dc.contributor.authorWu, X
dc.contributor.authorLu, KH
dc.contributor.authorLiang, D
dc.contributor.authorLevine, DA
dc.contributor.authorBisogna, M
dc.contributor.authorSchildkraut, JM
dc.contributor.authorBerchuck, A
dc.contributor.authorCramer, DW
dc.contributor.authorTerry, KL
dc.contributor.authorBandera, EV
dc.contributor.authorOlson, SH
dc.contributor.authorSalvesen, HB
dc.contributor.authorThomsen, LCV
dc.contributor.authorKopperud, RK
dc.contributor.authorBjorge, L
dc.contributor.authorKiemeney, LA
dc.contributor.authorMassuger, LFAG
dc.contributor.authorPejovic, T
dc.contributor.authorBruegl, A
dc.contributor.authorCook, LS
dc.contributor.authorLe, ND
dc.contributor.authorSwenerton, KD
dc.contributor.authorBrooks-Wilson, A
dc.contributor.authorKelemen, LE
dc.contributor.authorLubinski, J
dc.contributor.authorHuzarski, T
dc.contributor.authorGronwald, J
dc.contributor.authorMenkiszak, J
dc.contributor.authorWentzensen, N
dc.contributor.authorBrinton, L
dc.contributor.authorYang, H
dc.contributor.authorLissowska, J
dc.contributor.authorHogdall, CK
dc.contributor.authorLundvall, L
dc.contributor.authorSong, H
dc.contributor.authorTyrer, JP
dc.contributor.authorCampbell, I
dc.contributor.authorEccles, D
dc.contributor.authorPaul, J
dc.contributor.authorGlasspool, R
dc.contributor.authorSiddiqui, N
dc.contributor.authorWhittemore, AS
dc.contributor.authorSieh, W
dc.contributor.authorMcGuire, V
dc.contributor.authorRothstein, JH
dc.contributor.authorNarod, SA
dc.contributor.authorPhelan, C
dc.contributor.authorRisch, HA
dc.contributor.authorMcLaughlin, JR
dc.contributor.authorAnton-Culver, H
dc.contributor.authorZiogas, A
dc.contributor.authorMenon, U
dc.contributor.authorGayther, SA
dc.contributor.authorRamus, SJ
dc.contributor.authorGentry-Maharaj, A
dc.contributor.authorWu, AH
dc.contributor.authorPike, MC
dc.contributor.authorTseng, C-C
dc.contributor.authorKupryjanczyk, J
dc.contributor.authorDansonka-Mieszkowska, A
dc.contributor.authorBudzilowska, A
dc.contributor.authorRzepecka, IK
dc.contributor.authorWebb, PM
dc.date.accessioned2020-12-18T04:34:25Z
dc.date.available2020-12-18T04:34:25Z
dc.date.issued2018-04-01
dc.identifierpii: 10.1038/s41416-018-0011-3
dc.identifier.citationDixon-Suen, S. C., Nagle, C. M., Thrift, A. P., Pharoah, P. D. P., Ewing, A., Pearce, C. L., Zheng, W., Chenevix-Trench, G., Fasching, P. A., Beckmann, M. W., Lambrechts, D., Vergote, I., Lambrechts, S., Van Nieuwenhuysen, E., Rossing, M. A., Doherty, J. A., Wicklund, K. G., Chang-Claude, J., Jung, A. Y. ,... Webb, P. M. (2018). Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study. BRITISH JOURNAL OF CANCER, 118 (8), pp.1123-1129. https://doi.org/10.1038/s41416-018-0011-3.
dc.identifier.issn0007-0920
dc.identifier.urihttp://hdl.handle.net/11343/256255
dc.description.abstractBACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAdult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study
dc.typeJournal Article
dc.identifier.doi10.1038/s41416-018-0011-3
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentClinical Pathology
melbourne.source.titleBritish Journal of Cancer
melbourne.source.volume118
melbourne.source.issue8
melbourne.source.pages1123-1129
dc.rights.licenseCC BY
melbourne.elementsid1316459
melbourne.contributor.authorSouthey, Melissa
melbourne.contributor.authorCampbell, Ian
melbourne.contributor.authorGiles, Graham
melbourne.contributor.authorBruinsma, Fiona
melbourne.contributor.authorMilne, Roger
dc.identifier.eissn1532-1827
melbourne.accessrightsOpen Access


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