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    Resveratrol has protective effects against airway remodeling and airway hyperreactivity in a murine model of allergic airways disease.

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    Author
    Royce, SG; Dang, W; Yuan, G; Tran, J; El Osta, A; Karagiannis, TC; Tang, MLK
    Date
    2011
    Source Title
    Pathobiology of Aging & Age-related Diseases
    Publisher
    Informa UK Limited
    University of Melbourne Author/s
    El-Osta, Assam
    Affiliation
    Clinical Pathology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Royce, S. G., Dang, W., Yuan, G., Tran, J., El Osta, A., Karagiannis, T. C. & Tang, M. L. K. (2011). Resveratrol has protective effects against airway remodeling and airway hyperreactivity in a murine model of allergic airways disease.. Pathobiol Aging Age Relat Dis, 1 (1), pp.7134-7134. https://doi.org/10.3402/pba.v1i0.7134.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256261
    DOI
    10.3402/pba.v1i0.7134
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417665
    Abstract
    BACKGROUND: New therapies for asthma which can address three main interrelated features of the disease, airway inflammation, airway remodeling and airway hyperreactivity, are urgently required. Resveratrol, a well known red wine polyphenol has received much attention due to its potential anti-aging properties. This compound is an agonist of silent information regulator two histone deacetylases and has many effects that are relevant to key aspects of the pathophysiology of asthma including inflammation, cell proliferation and fibrosis. Therefore, resveratrol may offer a novel asthma therapy that simultaneously inhibits airway inflammation, and airway remodeling which are the main contributors to airway hyperreactivity and irreversible lung function loss. METHODS: We evaluated the effects of systemic resveratrol treatment in a murine model of chronic allergic airways disease which displays most of the clinicopathological features of severe human asthma. Wild-type Balb/c mice with allergic airways disease were treated with 12.5 mg/kg resveratrol or vehicle control. Airway inflammation was assessed by bronchoalveolar lavage fluid cell counts and histological examination of lung tissue sections. Further, remodeling was assessed by morphometric analysis and lung function was assessed by invasive plethysmography measurement of airway resistance and dynamic compliance. RESULTS: Mice treated with resveratrol exhibited reduced tissue inflammation as compared to vehicle treated mice (p<0.05). Additionally, resveratrol treatment resulted in reduced subepithelial collagen deposition as compared to vehicle treated mice (p<0.05) and attenuated airway hyperreactivity (p<0.05). CONCLUSIONS: These novel findings demonstrate that treatment with resveratrol can reduce structural airway remodeling changes and hyperreactivity. This has important implications for the development of new therapeutic approaches to asthma.

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