Show simple item record

dc.contributor.authorGood-Jacobson, KL
dc.contributor.authorGroom, JR
dc.date.accessioned2020-12-18T04:35:19Z
dc.date.available2020-12-18T04:35:19Z
dc.date.issued2018-03-08
dc.identifier.citationGood-Jacobson, K. L. & Groom, J. R. (2018). Tailoring Immune Responses toward Autoimmunity: Transcriptional Regulators That Drive the Creation and Collusion of Autoreactive Lymphocytes. FRONTIERS IN IMMUNOLOGY, 9 (MAR), https://doi.org/10.3389/fimmu.2018.00482.
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/11343/256262
dc.description.abstractT-dependent humoral immune responses to infection involve a collaboration between B and CD4 T cell activation, migration, and co-stimulation, thereby culminating in the formation of germinal centers (GCs) and eventual differentiation into memory cells and long-lived plasma cells (PCs). CD4 T cell-derived signals drive the formation of a tailored B cell response. Downstream of these signals are transcriptional regulators that are the critical enactors of immune cell programs. In particular, a core group of transcription factors regulate both B and T cell differentiation, identity, and function. The timing and expression levels of these transcription factors are tightly controlled, with dysregulated expression correlated to immune cell dysfunction in autoimmunity and lymphomagenesis. Recent studies have significantly advanced our understanding of both extrinsic and intrinsic regulators of autoreactive B cells and antibody-secreting PCs in systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune conditions. Yet, there are still gaps in our understanding of the causative role these regulators play, as well as the link between lymphoid responses and peripheral damage. This review will focus on the genesis of immunopathogenic CD4 helper and GC B cells. In particular, we will detail the transcriptional regulation of cytokine and chemokine receptor signaling during the pathogenesis of GC-derived autoimmune conditions in both murine models and human patients.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleTailoring Immune Responses toward Autoimmunity: Transcriptional Regulators That Drive the Creation and Collusion of Autoreactive Lymphocytes
dc.typeJournal Article
dc.identifier.doi10.3389/fimmu.2018.00482
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleFrontiers in Immunology
melbourne.source.volume9
melbourne.source.issueMAR
dc.rights.licenseCC BY
melbourne.elementsid1317678
melbourne.contributor.authorGroom, Joanna
dc.identifier.eissn1664-3224
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record