University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Clinical Pathology
  • Clinical Pathology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Clinical Pathology
  • Clinical Pathology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Effector CD4(+) T cells recognize intravascular antigen presented by patrolling monocytes

    Thumbnail
    Download
    Published version (6.089Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    17
    18
    Author
    Westhorpe, CLV; Norman, MU; Hall, P; Snelgrove, SL; Finsterbusch, M; Li, A; Lo, C; Tan, ZH; Li, S; Nilsson, SK; ...
    Date
    2018-02-21
    Source Title
    Nature Communications
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Nilsson, Susan
    Affiliation
    Clinical Pathology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Westhorpe, C. L. V., Norman, M. U., Hall, P., Snelgrove, S. L., Finsterbusch, M., Li, A., Lo, C., Tan, Z. H., Li, S., Nilsson, S. K., Kitching, A. R. & Hickey, M. J. (2018). Effector CD4(+) T cells recognize intravascular antigen presented by patrolling monocytes. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-018-03181-4.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256263
    DOI
    10.1038/s41467-018-03181-4
    Abstract
    Although effector CD4+ T cells readily respond to antigen outside the vasculature, how they respond to intravascular antigens is unknown. Here we show the process of intravascular antigen recognition using intravital multiphoton microscopy of glomeruli. CD4+ T cells undergo intravascular migration within uninflamed glomeruli. Similarly, while MHCII is not expressed by intrinsic glomerular cells, intravascular MHCII-expressing immune cells patrol glomerular capillaries, interacting with CD4+ T cells. Following intravascular deposition of antigen in glomeruli, effector CD4+ T-cell responses, including NFAT1 nuclear translocation and decreased migration, are consistent with antigen recognition. Of the MHCII+ immune cells adherent in glomerular capillaries, only monocytes are retained for prolonged durations. These cells can also induce T-cell proliferation in vitro. Moreover, monocyte depletion reduces CD4+ T-cell-dependent glomerular inflammation. These findings indicate that MHCII+ monocytes patrolling the glomerular microvasculature can present intravascular antigen to CD4+ T cells within glomerular capillaries, leading to antigen-dependent inflammation.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [52443]
    • Clinical Pathology - Research Publications [620]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors