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dc.contributor.authorWesthorpe, CLV
dc.contributor.authorNorman, MU
dc.contributor.authorHall, P
dc.contributor.authorSnelgrove, SL
dc.contributor.authorFinsterbusch, M
dc.contributor.authorLi, A
dc.contributor.authorLo, C
dc.contributor.authorTan, ZH
dc.contributor.authorLi, S
dc.contributor.authorNilsson, SK
dc.contributor.authorKitching, AR
dc.contributor.authorHickey, MJ
dc.date.accessioned2020-12-18T04:35:26Z
dc.date.available2020-12-18T04:35:26Z
dc.date.issued2018-02-21
dc.identifierpii: 10.1038/s41467-018-03181-4
dc.identifier.citationWesthorpe, C. L. V., Norman, M. U., Hall, P., Snelgrove, S. L., Finsterbusch, M., Li, A., Lo, C., Tan, Z. H., Li, S., Nilsson, S. K., Kitching, A. R. & Hickey, M. J. (2018). Effector CD4(+) T cells recognize intravascular antigen presented by patrolling monocytes. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-018-03181-4.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/256263
dc.description.abstractAlthough effector CD4+ T cells readily respond to antigen outside the vasculature, how they respond to intravascular antigens is unknown. Here we show the process of intravascular antigen recognition using intravital multiphoton microscopy of glomeruli. CD4+ T cells undergo intravascular migration within uninflamed glomeruli. Similarly, while MHCII is not expressed by intrinsic glomerular cells, intravascular MHCII-expressing immune cells patrol glomerular capillaries, interacting with CD4+ T cells. Following intravascular deposition of antigen in glomeruli, effector CD4+ T-cell responses, including NFAT1 nuclear translocation and decreased migration, are consistent with antigen recognition. Of the MHCII+ immune cells adherent in glomerular capillaries, only monocytes are retained for prolonged durations. These cells can also induce T-cell proliferation in vitro. Moreover, monocyte depletion reduces CD4+ T-cell-dependent glomerular inflammation. These findings indicate that MHCII+ monocytes patrolling the glomerular microvasculature can present intravascular antigen to CD4+ T cells within glomerular capillaries, leading to antigen-dependent inflammation.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEffector CD4(+) T cells recognize intravascular antigen presented by patrolling monocytes
dc.typeJournal Article
dc.identifier.doi10.1038/s41467-018-03181-4
melbourne.affiliation.departmentClinical Pathology
melbourne.source.titleNature Communications
melbourne.source.volume9
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1317753
melbourne.contributor.authorNilsson, Susan
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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