Identification of a novel lymphoid population in the murine epidermis.

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Almeida, FF; Tenno, M; Brzostek, J; Li, JL; Allies, G; Hoeffel, G; See, P; Ng, LG; Fehling, HJ; Gascoigne, NRJ; ...Date
2015-07-30Source Title
Scientific ReportsPublisher
Springer Science and Business Media LLCUniversity of Melbourne Author/s
de Almeida, FranciscaAffiliation
Medical Biology (W.E.H.I.)Metadata
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Almeida, F. F., Tenno, M., Brzostek, J., Li, J. L., Allies, G., Hoeffel, G., See, P., Ng, L. G., Fehling, H. J., Gascoigne, N. R. J., Taniuchi, I. & Ginhoux, F. (2015). Identification of a novel lymphoid population in the murine epidermis.. Sci Rep, 5 (1), pp.12554-. https://doi.org/10.1038/srep12554.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519784Abstract
T cell progenitors are known to arise from the foetal liver in embryos and the bone marrow in adults; however different studies have shown that a pool of T cell progenitors may also exist in the periphery. Here, we identified a lymphoid population resembling peripheral T cell progenitors which transiently seed the epidermis during late embryogenesis in both wild-type and T cell-deficient mice. We named these cells ELCs (Epidermal Lymphoid Cells). ELCs expressed Thy1 and CD2, but lacked CD3 and TCRαβ/γδ at their surface, reminiscent of the phenotype of extra- or intra- thymic T cell progenitors. Similarly to Dendritic Epidermal T Cells (DETCs), ELCs were radioresistant and capable of self-renewal. However, despite their progenitor-like phenotype and expression of T cell lineage markers within the population, ELCs did not differentiate into conventional T cells or DETCs in in vitro, ex vivo or in vivo differentiation assays. Finally, we show that ELC expressed NK markers and secreted IFN-γ upon stimulation. Therefore we report the discovery of a unique population of lymphoid cells within the murine epidermis that appears related to NK cells with as-yet-unidentified functions.
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