Identification of a novel lymphoid population in the murine epidermis.
AuthorAlmeida, FF; Tenno, M; Brzostek, J; Li, JL; Allies, G; Hoeffel, G; See, P; Ng, LG; Fehling, HJ; Gascoigne, NRJ; ...
Source TitleScientific Reports
PublisherSpringer Science and Business Media LLC
University of Melbourne Author/sde Almeida, Francisca
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsAlmeida, F. F., Tenno, M., Brzostek, J., Li, J. L., Allies, G., Hoeffel, G., See, P., Ng, L. G., Fehling, H. J., Gascoigne, N. R. J., Taniuchi, I. & Ginhoux, F. (2015). Identification of a novel lymphoid population in the murine epidermis.. Sci Rep, 5 (1), pp.12554-. https://doi.org/10.1038/srep12554.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519784
T cell progenitors are known to arise from the foetal liver in embryos and the bone marrow in adults; however different studies have shown that a pool of T cell progenitors may also exist in the periphery. Here, we identified a lymphoid population resembling peripheral T cell progenitors which transiently seed the epidermis during late embryogenesis in both wild-type and T cell-deficient mice. We named these cells ELCs (Epidermal Lymphoid Cells). ELCs expressed Thy1 and CD2, but lacked CD3 and TCRαβ/γδ at their surface, reminiscent of the phenotype of extra- or intra- thymic T cell progenitors. Similarly to Dendritic Epidermal T Cells (DETCs), ELCs were radioresistant and capable of self-renewal. However, despite their progenitor-like phenotype and expression of T cell lineage markers within the population, ELCs did not differentiate into conventional T cells or DETCs in in vitro, ex vivo or in vivo differentiation assays. Finally, we show that ELC expressed NK markers and secreted IFN-γ upon stimulation. Therefore we report the discovery of a unique population of lymphoid cells within the murine epidermis that appears related to NK cells with as-yet-unidentified functions.
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