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    Identification of a novel lymphoid population in the murine epidermis.

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    Author
    Almeida, FF; Tenno, M; Brzostek, J; Li, JL; Allies, G; Hoeffel, G; See, P; Ng, LG; Fehling, HJ; Gascoigne, NRJ; ...
    Date
    2015-07-30
    Source Title
    Scientific Reports
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    de Almeida, Francisca
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Almeida, F. F., Tenno, M., Brzostek, J., Li, J. L., Allies, G., Hoeffel, G., See, P., Ng, L. G., Fehling, H. J., Gascoigne, N. R. J., Taniuchi, I. & Ginhoux, F. (2015). Identification of a novel lymphoid population in the murine epidermis.. Sci Rep, 5 (1), pp.12554-. https://doi.org/10.1038/srep12554.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256264
    DOI
    10.1038/srep12554
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519784
    Abstract
    T cell progenitors are known to arise from the foetal liver in embryos and the bone marrow in adults; however different studies have shown that a pool of T cell progenitors may also exist in the periphery. Here, we identified a lymphoid population resembling peripheral T cell progenitors which transiently seed the epidermis during late embryogenesis in both wild-type and T cell-deficient mice. We named these cells ELCs (Epidermal Lymphoid Cells). ELCs expressed Thy1 and CD2, but lacked CD3 and TCRαβ/γδ at their surface, reminiscent of the phenotype of extra- or intra- thymic T cell progenitors. Similarly to Dendritic Epidermal T Cells (DETCs), ELCs were radioresistant and capable of self-renewal. However, despite their progenitor-like phenotype and expression of T cell lineage markers within the population, ELCs did not differentiate into conventional T cells or DETCs in in vitro, ex vivo or in vivo differentiation assays. Finally, we show that ELC expressed NK markers and secreted IFN-γ upon stimulation. Therefore we report the discovery of a unique population of lymphoid cells within the murine epidermis that appears related to NK cells with as-yet-unidentified functions.

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