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dc.contributor.authorAlmeida, FF
dc.contributor.authorTenno, M
dc.contributor.authorBrzostek, J
dc.contributor.authorLi, JL
dc.contributor.authorAllies, G
dc.contributor.authorHoeffel, G
dc.contributor.authorSee, P
dc.contributor.authorNg, LG
dc.contributor.authorFehling, HJ
dc.contributor.authorGascoigne, NRJ
dc.contributor.authorTaniuchi, I
dc.contributor.authorGinhoux, F
dc.date.accessioned2020-12-18T04:35:33Z
dc.date.available2020-12-18T04:35:33Z
dc.date.issued2015-07-30
dc.identifierpii: srep12554
dc.identifier.citationAlmeida, F. F., Tenno, M., Brzostek, J., Li, J. L., Allies, G., Hoeffel, G., See, P., Ng, L. G., Fehling, H. J., Gascoigne, N. R. J., Taniuchi, I. & Ginhoux, F. (2015). Identification of a novel lymphoid population in the murine epidermis.. Sci Rep, 5 (1), pp.12554-. https://doi.org/10.1038/srep12554.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/256264
dc.description.abstractT cell progenitors are known to arise from the foetal liver in embryos and the bone marrow in adults; however different studies have shown that a pool of T cell progenitors may also exist in the periphery. Here, we identified a lymphoid population resembling peripheral T cell progenitors which transiently seed the epidermis during late embryogenesis in both wild-type and T cell-deficient mice. We named these cells ELCs (Epidermal Lymphoid Cells). ELCs expressed Thy1 and CD2, but lacked CD3 and TCRαβ/γδ at their surface, reminiscent of the phenotype of extra- or intra- thymic T cell progenitors. Similarly to Dendritic Epidermal T Cells (DETCs), ELCs were radioresistant and capable of self-renewal. However, despite their progenitor-like phenotype and expression of T cell lineage markers within the population, ELCs did not differentiate into conventional T cells or DETCs in in vitro, ex vivo or in vivo differentiation assays. Finally, we show that ELC expressed NK markers and secreted IFN-γ upon stimulation. Therefore we report the discovery of a unique population of lymphoid cells within the murine epidermis that appears related to NK cells with as-yet-unidentified functions.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleIdentification of a novel lymphoid population in the murine epidermis.
dc.typeJournal Article
dc.identifier.doi10.1038/srep12554
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleScientific Reports
melbourne.source.volume5
melbourne.source.issue1
melbourne.source.pages12554-
dc.rights.licenseCC BY
melbourne.elementsid1317856
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519784
melbourne.contributor.authorde Almeida, Francisca
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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