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dc.contributor.authorRowe, CC
dc.contributor.authorDore, V
dc.contributor.authorJones, G
dc.contributor.authorBaxendale, D
dc.contributor.authorMulligan, RS
dc.contributor.authorBullich, S
dc.contributor.authorStephens, AW
dc.contributor.authorDe Santi, S
dc.contributor.authorMasters, CL
dc.contributor.authorDinkelborg, L
dc.contributor.authorVillemagne, VL
dc.date.accessioned2020-12-18T04:36:59Z
dc.date.available2020-12-18T04:36:59Z
dc.date.issued2017-11-01
dc.identifierpii: 10.1007/s00259-017-3749-6
dc.identifier.citationRowe, C. C., Dore, V., Jones, G., Baxendale, D., Mulligan, R. S., Bullich, S., Stephens, A. W., De Santi, S., Masters, C. L., Dinkelborg, L. & Villemagne, V. L. (2017). F-18-Florbetaben PET beta-amyloid binding expressed in Centiloids. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 44 (12), pp.2053-2059. https://doi.org/10.1007/s00259-017-3749-6.
dc.identifier.issn1619-7070
dc.identifier.urihttp://hdl.handle.net/11343/256276
dc.description.abstractPURPOSE: The Centiloid (CL) method enables quantitative values from Aβ-amyloid (Aβ) imaging to be expressed in a universal unit providing pathological, diagnostic and prognostic thresholds in clinical practice and research and allowing integration of multiple tracers and methods. The method was developed for 11C-PiB scans with zero CL set as the average in young normal subjects and 100 CL the average in subjects with mild Alzheimer's disease (AD). The method allows derivation of equations to convert the uptake value of any tracer into the same standard CL units but first requires head-to-head comparison with 11C-PiB results. We derived the equation to express 18F-florbetaben (FBB) binding in CL units. METHODS: Paired PiB and FBB PET scans were obtained in 35 subjects. including ten young normal subjects aged under 45 years (33 ± 8 years). FBB images were acquired from 90 to 110 min after injection. Spatially normalized images were analysed using the standard CL method (SPM8 coregistration of PET data to MRI data and the MNI-152 atlas) and standard CL regions (cortex and whole cerebellum downloaded from http://www.gaain.org ). RESULTS: FBB binding was strongly correlated with PiB binding (R 2 = 0.96, SUVRFBB = 0.61 × SUVRPiB + 0.39). The equation to derive CL values from FBB SUVR was CL units = 153.4 × SUVRFBB - 154.9. The CL value in the young normal subjects was -1.08 ± 6.81 for FBB scans compared to -0.32 ± 3.48 for PiB scans, giving a variance ratio of 1.96 (SDFBB CL/SDPiB CL). CONCLUSIONS: 18F-FBB binding is strongly correlated with PiB binding and FBB results can now be expressed in CL units.
dc.languageEnglish
dc.publisherSPRINGER
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleF-18-Florbetaben PET beta-amyloid binding expressed in Centiloids
dc.typeJournal Article
dc.identifier.doi10.1007/s00259-017-3749-6
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleEuropean Journal of Nuclear Medicine and Molecular Imaging
melbourne.source.volume44
melbourne.source.issue12
melbourne.source.pages2053-2059
melbourne.identifier.nhmrc1044361
melbourne.identifier.nhmrc1011689
dc.rights.licenseCC BY
melbourne.elementsid1217025
melbourne.contributor.authorVillemagne, Victor
melbourne.contributor.authorMasters, Colin
melbourne.contributor.authorRowe, Christopher
melbourne.contributor.authorBaxendale, David
dc.identifier.eissn1619-7089
melbourne.identifier.fundernameidNHMRC, 1044361
melbourne.identifier.fundernameidNHMRC, 1011689
melbourne.accessrightsOpen Access


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