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dc.contributor.authorAlshawaf, AJ
dc.contributor.authorAntonic, A
dc.contributor.authorSkafidas, E
dc.contributor.authorNg, DC-H
dc.contributor.authorDottori, M
dc.date.accessioned2020-12-18T04:41:41Z
dc.date.available2020-12-18T04:41:41Z
dc.date.issued2017-01-01
dc.identifier.citationAlshawaf, A. J., Antonic, A., Skafidas, E., Ng, D. C. -H. & Dottori, M. (2017). WDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells. STEM CELLS INTERNATIONAL, 2017, https://doi.org/10.1155/2017/7848932.
dc.identifier.issn1687-966X
dc.identifier.urihttp://hdl.handle.net/11343/256314
dc.description.abstractMutations in WD40-repeat protein 62 (WDR62) are commonly associated with primary microcephaly and other developmental cortical malformations. We used human pluripotent stem cells (hPSC) to examine WDR62 function during human neural differentiation and model early stages of human corticogenesis. Neurospheres lacking WDR62 expression showed decreased expression of intermediate progenitor marker, TBR2, and also glial marker, S100β. In contrast, inhibition of c-Jun N-terminal kinase (JNK) signalling during hPSC neural differentiation induced upregulation of WDR62 with a corresponding increase in neural and glial progenitor markers, PAX6 and EAAT1, respectively. These findings may signify a role of WDR62 in specifying intermediate neural and glial progenitors during human pluripotent stem cell differentiation.
dc.languageEnglish
dc.publisherHINDAWI LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleWDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells
dc.typeJournal Article
dc.identifier.doi10.1155/2017/7848932
melbourne.affiliation.departmentElectrical and Electronic Engineering
melbourne.affiliation.departmentBiomedical Engineering
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleStem Cells International
melbourne.source.volume2017
dc.rights.licenseCC BY
melbourne.elementsid1218845
melbourne.contributor.authorDottori, Mirella
melbourne.contributor.authorSkafidas, Efstratios
melbourne.contributor.authorAntonic-Baker, Ana
melbourne.contributor.authorAlshawaf, Abdullah
dc.identifier.eissn1687-9678
melbourne.accessrightsOpen Access


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