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dc.contributor.authorSu, YCF
dc.contributor.authorBahl, J
dc.contributor.authorJoseph, U
dc.contributor.authorButt, KM
dc.contributor.authorPeck, HA
dc.contributor.authorKoay, ESC
dc.contributor.authorOon, LLE
dc.contributor.authorBarr, IG
dc.contributor.authorVijaykrishna, D
dc.contributor.authorSmith, GJD
dc.date.accessioned2020-12-21T01:06:01Z
dc.date.available2020-12-21T01:06:01Z
dc.date.issued2015-08-01
dc.identifierpii: ncomms8952
dc.identifier.citationSu, Y. C. F., Bahl, J., Joseph, U., Butt, K. M., Peck, H. A., Koay, E. S. C., Oon, L. L. E., Barr, I. G., Vijaykrishna, D. & Smith, G. J. D. (2015). Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection. NATURE COMMUNICATIONS, 6 (1), https://doi.org/10.1038/ncomms8952.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/256366
dc.description.abstractInfluenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing evolutionary and global transmission dynamics of the virus remain poorly investigated. To address this we analyse >3,000 H1N1/2009 genomes, including 214 full genomes generated from our surveillance in Singapore, in conjunction with antigenic data. Here we show that natural selection acting on H1N1/2009 directly after introduction into humans was driven by adaptation to the new host. Since then, selection has been driven by immunological escape, with these changes corresponding to restricted antigenic diversity in the virus population. We also show that H1N1/2009 viruses have been subject to regular seasonal bottlenecks and a global reduction in antigenic and genetic diversity in 2014.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titlePhylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms8952
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleNature Communications
melbourne.source.volume6
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1219011
melbourne.contributor.authorBarr, Ian
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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