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dc.contributor.authorSchmaal, L
dc.contributor.authorVeltman, DJ
dc.contributor.authorvan Erp, TGM
dc.contributor.authorSaemann, PG
dc.contributor.authorFrodl, T
dc.contributor.authorJahanshad, N
dc.contributor.authorLoehrer, E
dc.contributor.authorTiemeier, H
dc.contributor.authorHofman, A
dc.contributor.authorNiessen, WJ
dc.contributor.authorVernooij, MW
dc.contributor.authorIkram, MA
dc.contributor.authorWittfeld, K
dc.contributor.authorGrabe, HJ
dc.contributor.authorBlock, A
dc.contributor.authorHegenscheid, K
dc.contributor.authorVoelzke, H
dc.contributor.authorHoehn, D
dc.contributor.authorCzisch, M
dc.contributor.authorLagopoulos, J
dc.contributor.authorHatton, SN
dc.contributor.authorHickie, IB
dc.contributor.authorGoya-Maldonado, R
dc.contributor.authorKraemer, B
dc.contributor.authorGruber, O
dc.contributor.authorCouvy-Duchesne, B
dc.contributor.authorRenteria, ME
dc.contributor.authorStrike, LT
dc.contributor.authorMills, NT
dc.contributor.authorde Zubicaray, GI
dc.contributor.authorMcMahon, KL
dc.contributor.authorMedland, SE
dc.contributor.authorMartin, NG
dc.contributor.authorGillespie, NA
dc.contributor.authorWright, MJ
dc.contributor.authorHall, GB
dc.contributor.authorMacQueen, GM
dc.contributor.authorFrey, EM
dc.contributor.authorCarballedo, A
dc.contributor.authorvan Velzen, LS
dc.contributor.authorvan Tol, MJ
dc.contributor.authorvan der Wee, NJ
dc.contributor.authorVeer, IM
dc.contributor.authorWalter, H
dc.contributor.authorSchnell, K
dc.contributor.authorSchramm, E
dc.contributor.authorNormann, C
dc.contributor.authorSchoepf, D
dc.contributor.authorKonrad, C
dc.contributor.authorZurowski, B
dc.contributor.authorNickson, T
dc.contributor.authorMcIntosh, AM
dc.contributor.authorPapmeyer, M
dc.contributor.authorWhalley, HC
dc.contributor.authorSussmann, JE
dc.contributor.authorGodlewska, BR
dc.contributor.authorCowen, PJ
dc.contributor.authorFischer, FH
dc.contributor.authorRose, M
dc.contributor.authorPenninx, BWJH
dc.contributor.authorThompson, PM
dc.contributor.authorHibar, DP
dc.date.accessioned2020-12-21T01:10:40Z
dc.date.available2020-12-21T01:10:40Z
dc.date.issued2016-06-01
dc.identifierpii: mp201569
dc.identifier.citationSchmaal, L., Veltman, D. J., van Erp, T. G. M., Saemann, P. G., Frodl, T., Jahanshad, N., Loehrer, E., Tiemeier, H., Hofman, A., Niessen, W. J., Vernooij, M. W., Ikram, M. A., Wittfeld, K., Grabe, H. J., Block, A., Hegenscheid, K., Voelzke, H., Hoehn, D., Czisch, M. ,... Hibar, D. P. (2016). Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. MOLECULAR PSYCHIATRY, 21 (6), pp.806-812. https://doi.org/10.1038/mp.2015.69.
dc.identifier.issn1359-4184
dc.identifier.urihttp://hdl.handle.net/11343/256400
dc.description.abstractThe pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls. Relative to controls, patients had significantly lower hippocampal volumes (Cohen's d=-0.14, % difference=-1.24). This effect was driven by patients with recurrent MDD (Cohen's d=-0.17, % difference=-1.44), and we detected no differences between first episode patients and controls. Age of onset ⩽21 was associated with a smaller hippocampus (Cohen's d=-0.20, % difference=-1.85) and a trend toward smaller amygdala (Cohen's d=-0.11, % difference=-1.23) and larger lateral ventricles (Cohen's d=0.12, % difference=5.11). Symptom severity at study inclusion was not associated with any regional brain volumes. Sample characteristics such as mean age, proportion of antidepressant users and proportion of remitted patients, and methodological characteristics did not significantly moderate alterations in brain volumes in MDD. Samples with a higher proportion of antipsychotic medication users showed larger caudate volumes in MDD patients compared with controls. This currently largest worldwide effort to identify subcortical brain alterations showed robust smaller hippocampal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode status.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleSubcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group
dc.typeJournal Article
dc.identifier.doi10.1038/mp.2015.69
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.source.titleMolecular Psychiatry
melbourne.source.volume21
melbourne.source.issue6
melbourne.source.pages806-812
melbourne.identifier.nhmrc1140764
dc.rights.licenseCC BY
melbourne.elementsid1086904
melbourne.contributor.authorSchmaal, Lianne
melbourne.contributor.authorvan Velzen, Laura
dc.identifier.eissn1476-5578
melbourne.identifier.fundernameidNHMRC, 1140764
melbourne.accessrightsOpen Access


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