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dc.contributor.authorWilson, D
dc.contributor.authorCharidimou, A
dc.contributor.authorAmbler, G
dc.contributor.authorFox, ZV
dc.contributor.authorGregoire, S
dc.contributor.authorRayson, P
dc.contributor.authorImaizumi, T
dc.contributor.authorFluri, F
dc.contributor.authorNaka, H
dc.contributor.authorHorstmann, S
dc.contributor.authorVeltkamp, R
dc.contributor.authorRothwell, PM
dc.contributor.authorKwa, VIH
dc.contributor.authorThijs, V
dc.contributor.authorLee, Y-S
dc.contributor.authorKim, YD
dc.contributor.authorHuang, Y
dc.contributor.authorWong, KS
dc.contributor.authorJager, HR
dc.contributor.authorWerring, DJ
dc.date.accessioned2020-12-21T01:15:51Z
dc.date.available2020-12-21T01:15:51Z
dc.date.issued2016-10-04
dc.identifierpii: WNL.0000000000003183
dc.identifier.citationWilson, D., Charidimou, A., Ambler, G., Fox, Z. V., Gregoire, S., Rayson, P., Imaizumi, T., Fluri, F., Naka, H., Horstmann, S., Veltkamp, R., Rothwell, P. M., Kwa, V. I. H., Thijs, V., Lee, Y. -S., Kim, Y. D., Huang, Y., Wong, K. S., Jager, H. R. & Werring, D. J. (2016). Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA A meta-analysis. NEUROLOGY, 87 (14), pp.1501-1510. https://doi.org/10.1212/wnl.0000000000003183.
dc.identifier.issn0028-3878
dc.identifier.urihttp://hdl.handle.net/11343/256436
dc.description.abstractOBJECTIVE: To determine associations between cerebral microbleed (CMB) burden with recurrent ischemic stroke (IS) and intracerebral hemorrhage (ICH) risk after IS or TIA. METHODS: We identified prospective studies of patients with IS or TIA that investigated CMBs and stroke (ICH and IS) risk during ≥3 months follow-up. Authors provided aggregate summary-level data on stroke outcomes, with CMBs categorized according to burden (single, 2-4, and ≥5 CMBs) and distribution. We calculated absolute event rates and pooled risk ratios (RR) using random-effects meta-analysis. RESULTS: We included 5,068 patients from 15 studies. There were 115/1,284 (9.6%) recurrent IS events in patients with CMBs vs 212/3,781 (5.6%) in patients without CMBs (pooled RR 1.8 for CMBs vs no CMBs; 95% confidence interval [CI] 1.4-2.5). There were 49/1,142 (4.3%) ICH events in those with CMBs vs 17/2,912 (0.58%) in those without CMBs (pooled RR 6.3 for CMBs vs no CMBs; 95% CI 3.5-11.4). Increasing CMB burden increased the risk of IS (pooled RR [95% CI] 1.8 [1.0-3.1], 2.4 [1.3-4.4], and 2.7 [1.5-4.9] for 1 CMB, 2-4 CMBs, and ≥5 CMBs, respectively) and ICH (pooled RR [95% CI] 4.6 [1.9-10.7], 5.6 [2.4-13.3], and 14.1 [6.9-29.0] for 1 CMB, 2-4 CMBs, and ≥5 CMBs, respectively). CONCLUSIONS: CMBs are associated with increased stroke risk after IS or TIA. With increasing CMB burden (compared to no CMBs), the risk of ICH increases more steeply than that of IS. However, IS absolute event rates remain higher than ICH absolute event rates in all CMB burden categories.
dc.languageEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleRecurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA A meta-analysis
dc.typeJournal Article
dc.identifier.doi10.1212/wnl.0000000000003183
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleNeurology
melbourne.source.volume87
melbourne.source.issue14
melbourne.source.pages1501-1510
dc.rights.licenseCC BY
melbourne.elementsid1095120
melbourne.contributor.authorThijs, Vincent
dc.identifier.eissn1526-632X
melbourne.accessrightsOpen Access


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