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dc.contributor.authorWen, W
dc.contributor.authorThalamuthu, A
dc.contributor.authorMather, KA
dc.contributor.authorZhu, W
dc.contributor.authorJiang, J
dc.contributor.authorde Micheaux, PL
dc.contributor.authorWright, MJ
dc.contributor.authorAmes, D
dc.contributor.authorSachdev, PS
dc.date.accessioned2020-12-21T01:16:02Z
dc.date.available2020-12-21T01:16:02Z
dc.date.issued2016-09-06
dc.identifierpii: srep32760
dc.identifier.citationWen, W., Thalamuthu, A., Mather, K. A., Zhu, W., Jiang, J., de Micheaux, P. L., Wright, M. J., Ames, D. & Sachdev, P. S. (2016). Distinct Genetic Influences on Cortical and Subcortical Brain Structures. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep32760.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/256437
dc.description.abstractThis study examined the heritability of brain grey matter structures in a subsample of older adult twins (93 MZ and 68 DZ twin pairs; mean age 70 years) from the Older Australian Twins Study. The heritability estimates of subcortical regions ranged from 0.41 (amygdala) to 0.73 (hippocampus), and of cortical regions, from 0.55 (parietal lobe) to 0.78 (frontal lobe). Corresponding structures in the two hemispheres were influenced by the same genetic factors and high genetic correlations were observed between the two hemispheric regions. There were three genetically correlated clusters, comprising (i) the cortical lobes (frontal, temporal, parietal and occipital lobes); (ii) the basal ganglia (caudate, putamen and pallidum) with weak genetic correlations with cortical lobes, and (iii) the amygdala, hippocampus, thalamus and nucleus accumbens grouped together, which genetically correlated with both basal ganglia and cortical lobes, albeit relatively weakly. Our study demonstrates a complex but patterned and clustered genetic architecture of the human brain, with divergent genetic determinants of cortical and subcortical structures, in particular the basal ganglia.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleDistinct Genetic Influences on Cortical and Subcortical Brain Structures
dc.typeJournal Article
dc.identifier.doi10.1038/srep32760
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleScientific Reports
melbourne.source.volume6
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1095306
melbourne.contributor.authorAmes, David
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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