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dc.contributor.authorYap, TW-C
dc.contributor.authorLeow, AH-R
dc.contributor.authorAzmi, AN
dc.contributor.authorCallahan, DL
dc.contributor.authorPerez-Perez, GI
dc.contributor.authorLoke, M-F
dc.contributor.authorGoh, K-L
dc.contributor.authorVadiyelu, J
dc.date.accessioned2020-12-21T01:18:03Z
dc.date.available2020-12-21T01:18:03Z
dc.date.issued2017-03-30
dc.identifier.citationYap, T. W. -C., Leow, A. H. -R., Azmi, A. N., Callahan, D. L., Perez-Perez, G. I., Loke, M. -F., Goh, K. -L. & Vadiyelu, J. (2017). Global Fecal and Plasma Metabolic Dynamics Related to Helicobacter pylori Eradication. FRONTIERS IN MICROBIOLOGY, 8 (MAR), https://doi.org/10.3389/fmicb.2017.00536.
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/11343/256451
dc.description.abstractBackground:Helicobacter pylori colonizes the gastric mucosa of more than half of the world's population. There is increasing evidence H. pylori protects against the development of obesity and childhood asthma/allergies in which the development of these diseases coincide with transient dysbiosis. However, the mechanism underlying the association of H. pylori eradication with human metabolic and immunological disorders is not well-established. In this study, we aimed to investigate the local and systemic effects of H. pylori eradication through untargeted fecal lipidomics and plasma metabolomics approaches by liquid chromatography mass spectrometry (LC-MS). Results: Our study revealed that eradication of H. pylori eradication (i.e., loss of H. pylori and/or H. pylori eradication therapy) changed many global metabolite/lipid features, with the majority being down-regulated. Our findings primarily show that H. pylori eradication affects the host energy and lipid metabolism which may eventually lead to the development of metabolic disorders. Conclusion: These predictive metabolic signatures of metabolic and immunological disorders following H. pylori eradication can provide insights into dynamic local and systemic metabolism related to H. pylori eradication in modulating human health.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.titleGlobal Fecal and Plasma Metabolic Dynamics Related to Helicobacter pylori Eradication
dc.typeJournal Article
dc.identifier.doi10.3389/fmicb.2017.00536
melbourne.affiliation.departmentSchool of BioSciences
melbourne.source.titleFrontiers in Microbiology
melbourne.source.volume8
melbourne.source.issueMAR
dc.rights.licenseCC BY
melbourne.elementsid1222880
melbourne.contributor.authorCALLAHAN, DAMIEN
dc.identifier.eissn1664-302X
melbourne.accessrightsOpen Access


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