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    Host age and expression of genes involved in red blood cell invasion in Plasmodium falciparum field isolates

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    Author
    Valmaseda, A; Bassat, Q; Aide, P; Cistero, P; Jimenez, A; Casellas, A; Machevo, S; Aguilar, R; Sigauque, B; Chauhan, VS; ...
    Date
    2017-07-05
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Beeson, James
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Valmaseda, A., Bassat, Q., Aide, P., Cistero, P., Jimenez, A., Casellas, A., Machevo, S., Aguilar, R., Sigauque, B., Chauhan, V. S., Langer, C., Beeson, J., Chitnis, C., Alonso, P. L., Gaur, D. & Mayor, A. (2017). Host age and expression of genes involved in red blood cell invasion in Plasmodium falciparum field isolates. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-05025-5.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256467
    DOI
    10.1038/s41598-017-05025-5
    Abstract
    Plasmodium falciparum proteins involved in erythrocyte invasion are main targets of acquired immunity and important vaccine candidates. We hypothesized that anti-parasite immunity acquired upon exposure would limit invasion-related gene (IRG) expression and affect the clinical impact of the infection. 11 IRG transcript levels were measured in P. falciparum isolates by RT-PCR, and IgG/IgM against invasion ligands by Luminex®, in 50 Mozambican adults, 25 children with severe malaria (SM) and 25 with uncomplicated malaria (UM). IRG expression differences among groups and associations between IRG expression and clinical/immunologic parameters were assessed. IRG expression diversity was higher in parasites infecting children than adults (p = 0.022). eba140 and ptramp expression decreased with age (p = 0.003 and 0.007, respectively) whereas p41 expression increased (p = 0.022). pfrh5 reduction in expression was abrupt early in life. Parasite density decreased with increasing pfrh5 expression (p < 0.001) and, only in children, parasite density increased with p41 expression (p = 0.007), and decreased with eba175 (p = 0.013). Antibody responses and IRG expression were not associated. In conclusion, IRG expression is associated with age and parasite density, but not with specific antibody responses in the acute phase of infection. Our results confirm the importance of multi-antigen vaccines development to avoid parasite immune escape when tested in malaria-exposed individuals.

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