University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Rural Clinical School
  • Rural Clinical School - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Rural Clinical School
  • Rural Clinical School - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes

    Thumbnail
    Download
    published version (411.2Kb)

    Citations
    Scopus
    Web of Science
    Altmetric
    6
    6
    Author
    Zhou, Y; Simmons, D; Hambly, BD; McLachlan, CS
    Date
    2016-09-12
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Simmons, David
    Affiliation
    Rural Clinical School
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Zhou, Y., Simmons, D., Hambly, B. D. & McLachlan, C. S. (2016). Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep33147.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256468
    DOI
    10.1038/srep33147
    Abstract
    Mitochondrial uncoupling protein 2 (UCP2) can affect oxidative stress levels. UCP2 polymorphisms are associated with leukocyte telomere length (LTL) in Type 2 Diabetes, which also induces considerable background oxidative stress. The effects of UCP2 polymorphisms on LTL in populations without diabetes have not been well described. Our aims are to evaluate the interaction between LTL and UCP2 polymorphisms in 950 subjects without diabetes. The monochrome multiplex quantitative PCR method was used to measure relative LTL. Taqman SNP genotyping assay was applied to genotypes for UCP2 rs659366 and rs660339. We found shorter LTL associated with increased age (P < 0.001) and triglyceride levels (P = 0.041). After adjustment for cardiovascular risk factors, rs659336 GG genotype carriers demonstrated a shorter LTL (1.257 ± 0.186), compared to GA carriers (1.288 ± 0.230, P = 0.022) and AA carriers (1.314 ± 0.253, P = 0.002). LTL was shorter in the CC rs660339 genotype (1.254 ± 0.187) compared to TT (1.297 ± 0.242, P = 0.007) and CT carriers (1.292 ± 0.229, P = 0.016). The T allele of rs660339 is associated with a longer LTL of approximately 0.04 compared to CC homozygotes. Thus, UCP2 rs659366 A allele and rs660339 T allele are both related to longer LTL in subjects without diabetes, independent of cardiovascular risk factors.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53102]
    • Rural Clinical School - Research Publications [147]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors