Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression

Download
Author
Egorova, N; Veldsman, M; Cumming, T; Brodtmann, ADate
2017-01-01Source Title
NeuroImage: ClinicalPublisher
ELSEVIER SCI LTDAffiliation
PhysiotherapyMedicine and Radiology
Florey Department of Neuroscience and Mental Health
Melbourne School of Psychological Sciences
Metadata
Show full item recordDocument Type
Journal ArticleCitations
Egorova, N., Veldsman, M., Cumming, T. & Brodtmann, A. (2017). Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression. NEUROIMAGE-CLINICAL, 16, pp.116-124. https://doi.org/10.1016/j.nicl.2017.07.014.Access Status
Open AccessNHMRC Grant code
NHMRC/1045617Abstract
Depression is a common outcome following stroke, associated with reduced quality of life and poorer recovery. Despite attempts to associate depression symptoms with specific lesion sites, the neural basis of post-stroke depression remains poorly understood. Resting state fMRI has provided new insights into the neural underpinnings of post-stroke depression, but has been limited to connectivity analyses exploring interregional correlations in the time-course of activity. Other aspects of resting state BOLD signal remain unexamined. Measuring the amplitude of low frequency fluctuations allows the detection of spontaneous neural activity across the whole brain. It provides complementary information about frequency-specific local neural activity. We calculated the fractional amplitude of low frequency fluctuations (fALFF) in a group of 64 participants scanned 3 months post-stroke. Twenty showed depression symptoms when assessed with the Patient Health Questionnaire (PHQ-9). We performed analyses in both the typical 0.01-0.08 Hz range, as well as separately in the slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz) ranges. We found significantly higher fALFF in the depressed compared to non-depressed participants in the left dorsolateral prefrontal cortex (DLPFC) and the right precentral gyrus, and a significant association between higher depression scores and higher fALFF in the left insula. The group differences were detected in the slow-5 fluctuations, while the association with depression severity was observed in the slow-4 range. We conclude that post-stroke depression can be characterised by aberrant spontaneous local neural activity, which in small samples could be a more sensitive measure than lesion volume and location.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References