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dc.contributor.authorBushell, E
dc.contributor.authorGomes, AR
dc.contributor.authorSanderson, T
dc.contributor.authorAnar, B
dc.contributor.authorGirling, G
dc.contributor.authorHerd, C
dc.contributor.authorMetcalf, T
dc.contributor.authorModrzynska, K
dc.contributor.authorSchwach, F
dc.contributor.authorMartin, RE
dc.contributor.authorMather, MW
dc.contributor.authorMcFadden, GI
dc.contributor.authorParts, L
dc.contributor.authorRutledge, GG
dc.contributor.authorVaidya, AB
dc.contributor.authorWengelnik, K
dc.contributor.authorRayner, JC
dc.contributor.authorBillker, O
dc.date.accessioned2020-12-21T01:26:40Z
dc.date.available2020-12-21T01:26:40Z
dc.date.issued2017-07-13
dc.identifierpii: S0092-8674(17)30714-6
dc.identifier.citationBushell, E., Gomes, A. R., Sanderson, T., Anar, B., Girling, G., Herd, C., Metcalf, T., Modrzynska, K., Schwach, F., Martin, R. E., Mather, M. W., McFadden, G. I., Parts, L., Rutledge, G. G., Vaidya, A. B., Wengelnik, K., Rayner, J. C. & Billker, O. (2017). Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. CELL, 170 (2), pp.260-+. https://doi.org/10.1016/j.cell.2017.06.030.
dc.identifier.issn0092-8674
dc.identifier.urihttp://hdl.handle.net/11343/256513
dc.description.abstractThe genomes of malaria parasites contain many genes of unknown function. To assist drug development through the identification of essential genes and pathways, we have measured competitive growth rates in mice of 2,578 barcoded Plasmodium berghei knockout mutants, representing >50% of the genome, and created a phenotype database. At a single stage of its complex life cycle, P. berghei requires two-thirds of genes for optimal growth, the highest proportion reported from any organism and a probable consequence of functional optimization necessitated by genomic reductions during the evolution of parasitism. In contrast, extreme functional redundancy has evolved among expanded gene families operating at the parasite-host interface. The level of genetic redundancy in a single-celled organism may thus reflect the degree of environmental variation it experiences. In the case of Plasmodium parasites, this helps rationalize both the relative successes of drugs and the greater difficulty of making an effective vaccine.
dc.languageEnglish
dc.publisherCELL PRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleFunctional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes
dc.typeJournal Article
dc.identifier.doi10.1016/j.cell.2017.06.030
melbourne.affiliation.departmentSchool of BioSciences
melbourne.source.titleCell
melbourne.source.volume170
melbourne.source.issue2
melbourne.source.pages260-+
dc.rights.licenseCC BY
melbourne.elementsid1221629
melbourne.contributor.authorMcFadden, Geoffrey
dc.identifier.eissn1097-4172
melbourne.accessrightsOpen Access


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