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dc.contributor.authorAshique, AM
dc.contributor.authorHart, LS
dc.contributor.authorThomas, CDL
dc.contributor.authorClement, JG
dc.contributor.authorPivonka, P
dc.contributor.authorCarter, Y
dc.contributor.authorMousseau, DD
dc.contributor.authorCooper, DML
dc.date.accessioned2020-12-21T01:33:01Z
dc.date.available2020-12-21T01:33:01Z
dc.date.issued2017-12
dc.identifierpii: S2352-1872(17)30018-9
dc.identifier.citationAshique, A. M., Hart, L. S., Thomas, C. D. L., Clement, J. G., Pivonka, P., Carter, Y., Mousseau, D. D. & Cooper, D. M. L. (2017). Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity.. Bone Rep, 7, pp.9-16. https://doi.org/10.1016/j.bonr.2017.06.002.
dc.identifier.issn2352-1872
dc.identifier.urihttp://hdl.handle.net/11343/256557
dc.description.abstractThe lacunar-canalicular network (LCN) of bone contains osteocytes and their dendritic extensions, which allow for intercellular communication, and are believed to serve as the mechanosensors that coordinate the processes of bone modeling and remodeling. Imbalances in remodeling, for example, are linked to bone disease, including fragility associated with aging. We have reported that there is a reduction in scale for one component of the LCN, osteocyte lacunar volume, across the human lifespan in females. In the present study, we explore the hypothesis that canalicular porosity also declines with age. To visualize the LCN and to determine how its components are altered with aging, we examined samples from young (age: 20-23 y; n = 5) and aged (age: 70-86 y; n = 6) healthy women donors utilizing a fluorescent labelling technique in combination with confocal laser scanning microscopy. A large cross-sectional area of cortical bone spanning the endosteal to periosteal surfaces from the anterior proximal femoral shaft was examined in order to account for potential trans-cortical variation in the LCN. Overall, we found that LCN areal fraction was reduced by 40.6% in the samples from aged women. This reduction was due, in part, to a reduction in lacunar density (21.4% decline in lacunae number per given area of bone), but much more so due to a 44.6% decline in canalicular areal fraction. While the areal fraction of larger vascular canals was higher in endosteal vs. periosteal regions for both age groups, no regional differences were observed in the areal fractions of the LCN and its components for either age group. Our data indicate that the LCN is diminished in aged women, and is largely due to a decline in the canalicular areal fraction, and that, unlike vascular canal porosity, this diminished LCN is uniform across the cortex.
dc.languageeng
dc.publisherElsevier BV
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleLacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity.
dc.typeJournal Article
dc.identifier.doi10.1016/j.bonr.2017.06.002
melbourne.affiliation.departmentSurgery (St Vincent's)
melbourne.affiliation.departmentMelbourne Dental School
melbourne.source.titleBone Reports
melbourne.source.volume7
melbourne.source.pages9-16
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1224210
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517690
melbourne.contributor.authorPivonka, Peter
melbourne.contributor.authorClement, John
melbourne.contributor.authorThomas, Christopher
dc.identifier.eissn2352-1872
melbourne.accessrightsOpen Access


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