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dc.contributor.authorHatch, RJ
dc.contributor.authorMendis, GDC
dc.contributor.authorKaila, K
dc.contributor.authorReid, CA
dc.contributor.authorPetrou, S
dc.date.accessioned2020-12-21T01:34:09Z
dc.date.available2020-12-21T01:34:09Z
dc.date.issued2017-07-17
dc.identifier.citationHatch, R. J., Mendis, G. D. C., Kaila, K., Reid, C. A. & Petrou, S. (2017). Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex. FRONTIERS IN CELLULAR NEUROSCIENCE, 11, https://doi.org/10.3389/fncel.2017.00204.
dc.identifier.issn1662-5102
dc.identifier.urihttp://hdl.handle.net/11343/256565
dc.description.abstractGap junctions form electrical synapses that modulate neuronal activity by synchronizing action potential (AP) firing of cortical interneurons (INs). Gap junctions are thought to form predominantly within cortical INs of the same functional class and are therefore considered to act within discrete neuronal populations. Here, we challenge that view and show that the probability of electrical coupling is the same within and between regular-spiking (RS) and fast-spiking (FS) cortical INs in 16-21 days old mice. Firing properties of these two populations were distinct from other INs types including neurogliaform and low-threshold spiking (LTS) cells. We also demonstrate that pre-junctional APs can depolarize post-junctional neurons and increase the probability of firing. Our findings of frequent gap junction coupling between functionally distinct IN subtypes suggest that cortical IN networks are much more extensive and heterogeneous than previously thought. This may have implications on mechanisms ranging from cognitive functions to modulation of pathological states in epilepsy and other neurological disorders.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex
dc.typeJournal Article
dc.identifier.doi10.3389/fncel.2017.00204
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFrontiers in Cellular Neuroscience
melbourne.source.volume11
dc.rights.licenseCC BY
melbourne.elementsid1224587
melbourne.contributor.authorPetrou, Steven
melbourne.contributor.authorReid, Christopher
melbourne.contributor.authorHatch, Robert
melbourne.contributor.authorMendis, Gunarathna Dulini Chathurika
dc.identifier.eissn1662-5102
melbourne.accessrightsOpen Access


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