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dc.contributor.authorBhaskar, S
dc.contributor.authorBivard, A
dc.contributor.authorStanwell, P
dc.contributor.authorAttia, JR
dc.contributor.authorParsons, M
dc.contributor.authorNilsson, M
dc.contributor.authorLevi, C
dc.date.accessioned2020-12-21T01:35:09Z
dc.date.available2020-12-21T01:35:09Z
dc.date.issued2016-12-05
dc.identifierpii: srep38525
dc.identifier.citationBhaskar, S., Bivard, A., Stanwell, P., Attia, J. R., Parsons, M., Nilsson, M. & Levi, C. (2016). Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep38525.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/256571
dc.description.abstractDelay in cortical vein filling during the late-venous phase (delayed-LCVF) is characterized by opacification of cerebral veins despite contrast clearance from contralateral veins on dynamic computed tomography angiography (dCTA) in acute ischemic stroke (AIS) patients. The aim of the study was to investigate the associations of delayed-LCVF with clot location, reperfusion status at 24 hours, and 90-days functional outcome in AIS patients who received reperfusion therapy. A prospective cohort of AIS patients treated with intravenous thrombolysis was studied. Groupwise comparison, univariate, and multivariate regression analyses were used to study the association of delayed-LCVF with clot location and clinical outcomes. Of 93 patients (mean age = 72 ± 12 years) with hemispheric AIS included in the study, 46 (49%) demonstrated delayed-LCVF. Patients with delayed-LCVF demonstrated a significantly higher proportion of proximal occlusion (72% vs 13%, P =< 0.0001), and poor reperfusion at 24 hours (41% vs 11%, P = 0.001). The proportion of poor functional outcome at 90 days was not significantly different (22/56 (48%) vs 17/61 (36%), P = 0.297). The appearance of delayed-LCVF on baseline dCTA may be a surrogate for large vessel occlusion, and an early marker for poor 24-hour angiographic reperfusion.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAssociation of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients
dc.typeJournal Article
dc.identifier.doi10.1038/srep38525
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Reports
melbourne.source.volume6
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1225792
melbourne.contributor.authorParsons, Mark
melbourne.contributor.authorBivard, Andrew
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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