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dc.contributor.authorTong, A
dc.contributor.authorTong, SYC
dc.contributor.authorZhang, Y
dc.contributor.authorLamlertthon, S
dc.contributor.authorSharma-Kuinkel, BK
dc.contributor.authorRude, T
dc.contributor.authorAhn, SH
dc.contributor.authorRuffin, F
dc.contributor.authorLlorens, L
dc.contributor.authorTamarana, G
dc.contributor.authorBiek, D
dc.contributor.authorCritchley, I
dc.contributor.authorFowler, VG
dc.date.accessioned2020-12-21T01:37:13Z
dc.date.available2020-12-21T01:37:13Z
dc.date.issued2012-05-18
dc.identifierpii: PONE-D-12-05970
dc.identifier.citationTong, A., Tong, S. Y. C., Zhang, Y., Lamlertthon, S., Sharma-Kuinkel, B. K., Rude, T., Ahn, S. H., Ruffin, F., Llorens, L., Tamarana, G., Biek, D., Critchley, I. & Fowler, V. G. (2012). Panton-Valentine Leukocidin Is Not the Primary Determinant of Outcome for Staphylococcus aureus Skin Infections: Evaluation from the CANVAS Studies. PLOS ONE, 7 (5), https://doi.org/10.1371/journal.pone.0037212.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/256586
dc.description.abstractThe impact of Panton-Valentine leukocidin (PVL) on the severity of complicated skin and skin structure infections (cSSSI) caused by Staphylococcus aureus is controversial. We evaluated potential associations between clinical outcome and PVL presence in both methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolates from patients enrolled in two large, multinational phase three clinical trials assessing ceftaroline fosamil for the treatment of cSSSI (the CANVAS 1 and 2 programs). Isolates from all microbiologically evaluable patients with monomicrobial MRSA or MSSA infections (n = 473) were genotyped by PCR for pvl and underwent pulsed-field gel electrophoresis (PFGE). Genes encoding pvl were present in 266/473 (56.2%) isolates. Infections caused by pvl-positive S. aureus were associated with younger patient age, North American acquisition, and presence of major abscesses (P<0.001 for each). Cure rates of patients infected with pvl-positive and pvl-negative S. aureus were similar overall (93.6% versus 92.8%; P = 0.72), and within MRSA-infected (94.5% vs. 93.1%; P = 0.67) and MSSA-infected patients (92.2% vs. 92.7%; P = 1.00). This finding persisted after adjustment for multiple patient characteristics. Outcomes were also similar when USA300 PVL+ and non-USA300 PVL+ infections were compared. The results of this contemporary, international study suggest that pvl presence was not the primary determinant of outcome in patients with cSSSI due to either MRSA or MSSA.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.titlePanton-Valentine Leukocidin Is Not the Primary Determinant of Outcome for Staphylococcus aureus Skin Infections: Evaluation from the CANVAS Studies
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0037212
melbourne.affiliation.departmentDoherty Institute
melbourne.source.titlePLoS One
melbourne.source.volume7
melbourne.source.issue5
dc.rights.licenseCC BY
melbourne.elementsid1225412
melbourne.contributor.authorTong, Steven
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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