Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium

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    Author
    Lophatananon, A; Stewart-Brown, S; Kote-Jarai, Z; Al Olama, AA; Garcia, SB; Neal, DE; Hamdy, FC; Donovan, JL; Giles, GG; Fitzgerald, LM; ...
    Date
    2017-08-22
    Source Title
    British Journal of Cancer
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Southey, Melissa; Hopper, John; Giles, Graham
    Affiliation
    Melbourne School of Population and Global Health
    Clinical Pathology
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    Document Type
    Journal Article
    Citations
    Lophatananon, A., Stewart-Brown, S., Kote-Jarai, Z., Al Olama, A. A., Garcia, S. B., Neal, D. E., Hamdy, F. C., Donovan, J. L., Giles, G. G., Fitzgerald, L. M., Southey, M. C., Pharoah, P., Pashayan, N., Gronberg, H., Wiklund, F., Aly, M., Stanford, J. L., Brenner, H., Dieffenbach, A. K. ,... Muir, K. (2017). Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium. BRITISH JOURNAL OF CANCER, 117 (5), pp.734-743. https://doi.org/10.1038/bjc.2017.231.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256603
    DOI
    10.1038/bjc.2017.231
    Abstract
    BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. METHODS: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions. RESULTS: The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01-1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group. CONCLUSIONS: There was no evidence of gene-environment interaction between height and the selected candidate SNPs.Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.

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