Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia

Download
Author
Grist, EPM; Flegg, JA; Humphreys, G; Mas, IS; Anderson, TJC; Ashley, EA; Day, NPJ; Dhorda, M; Dondorp, AM; Abul Faiz, M; ...Date
2016-10-24Source Title
International Journal of Health GeographicsPublisher
BMCUniversity of Melbourne Author/s
Flegg, JenniferAffiliation
School of Mathematics and StatisticsMetadata
Show full item recordDocument Type
Journal ArticleCitations
Grist, E. P. M., Flegg, J. A., Humphreys, G., Mas, I. S., Anderson, T. J. C., Ashley, E. A., Day, N. P. J., Dhorda, M., Dondorp, A. M., Abul Faiz, M., Gething, P. W., Hien, T. T., Hlaing, T. M., Imwong, M., Kindermans, J. -M., Maude, R. J., Mayxay, M., McDew-White, M., Menard, D. ,... Guerin, P. J. (2016). Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia. INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS, 15 (1), https://doi.org/10.1186/s12942-016-0064-6.Access Status
Open AccessAbstract
BACKGROUND: Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their spatial distribution. These efforts require substantial resources. Here we propose a generic 'smart surveillance' methodology to identify optimal candidate sites for future sampling and thus map the distribution of artemisinin resistance most efficiently. METHODS: The approach uses the 'uncertainty' map generated iteratively by a geostatistical model to determine optimal locations for subsequent sampling. RESULTS: The methodology is illustrated using recent data on the prevalence of the K13-propeller polymorphism (a genetic marker of artemisinin resistance) in the Greater Mekong Subregion. CONCLUSION: This methodology, which has broader application to geostatistical mapping in general, could improve the quality and efficiency of drug resistance mapping and thereby guide practical operations to eliminate malaria in affected areas.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References