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dc.contributor.authorVian, J
dc.contributor.authorPereira, C
dc.contributor.authorChavarria, V
dc.contributor.authorKohler, C
dc.contributor.authorStubbs, B
dc.contributor.authorQuevedo, J
dc.contributor.authorKing, SW
dc.contributor.authorCarvalho, AF
dc.contributor.authorBerk, M
dc.contributor.authorFernandes, BS
dc.date.accessioned2020-12-21T01:45:24Z
dc.date.available2020-12-21T01:45:24Z
dc.date.issued2017-08-01
dc.identifierpii: 10.1186/s12916-017-0916-3
dc.identifier.citationVian, J., Pereira, C., Chavarria, V., Kohler, C., Stubbs, B., Quevedo, J., King, S. W., Carvalho, A. F., Berk, M. & Fernandes, B. S. (2017). The renin-angiotensin system: a possible new target for depression. BMC MEDICINE, 15 (1), https://doi.org/10.1186/s12916-017-0916-3.
dc.identifier.issn1741-7015
dc.identifier.urihttp://hdl.handle.net/11343/256645
dc.description.abstractDepression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin-angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin-angiotensin system have yielded promising results. Here, we review the potential beneficial effects of angiotensin blockers in depression and their mechanisms of action. Drugs blocking the angiotensin system have efficacy in several animal models of depression. While no randomised clinical trials were found, case reports and observational studies showed that angiotensin-converting enzyme inhibitors or angiotensin receptor blockers had positive effects on depression, whereas other antihypertensive agents did not. Drugs targeting the renin-angiotensin system act on inflammatory pathways implicated in depression. Both preclinical and clinical data suggest that these drugs possess antidepressant properties. In light of these results, angiotensin system-blocking agents offer new horizons in mood disorder treatment.
dc.languageEnglish
dc.publisherBMC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe renin-angiotensin system: a possible new target for depression
dc.typeJournal Article
dc.identifier.doi10.1186/s12916-017-0916-3
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleBMC Medicine
melbourne.source.volume15
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1226417
melbourne.contributor.authorBerk, Michael
dc.identifier.eissn1741-7015
melbourne.accessrightsOpen Access


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