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    Hurdles in Basic Science Translation

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    Author
    Perry, CJ; Lawrence, AJ
    Date
    2017-07-18
    Source Title
    Frontiers in Pharmacology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Lawrence, Andrew; Perry, Christina
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Perry, C. J. & Lawrence, A. J. (2017). Hurdles in Basic Science Translation. FRONTIERS IN PHARMACOLOGY, 8 (JUL), https://doi.org/10.3389/fphar.2017.00478.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256646
    DOI
    10.3389/fphar.2017.00478
    Abstract
    In the past century there have been incredible advances in the field of medical research, but what hinders translation of this knowledge into effective treatment for human disease? There is an increasing focus on the failure of many research breakthroughs to be translated through the clinical trial process and into medical practice. In this mini review, we will consider some of the reasons that findings in basic medical research fail to become translated through clinical trials and into basic medical practices. We focus in particular on the way that human disease is modeled, the understanding we have of how our targets behave in vivo, and also some of the issues surrounding reproducibility of basic research findings. We will also look at some of the ways that have been proposed for overcoming these issues. It appears that there needs to be a cultural shift in the way we fund, publish and recognize quality control in scientific research. Although this is a daunting proposition, we hope that with increasing awareness and focus on research translation and the hurdles that impede it, the field of medical research will continue to inform and improve medical practice across the world.

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