Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases
AuthorJoosten, SA; Sullivan, LC; Ottenhoff, THM
Source TitleJournal of Immunology Research
University of Melbourne Author/sSullivan, Lucy
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsJoosten, S. A., Sullivan, L. C. & Ottenhoff, T. H. M. (2016). Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases. JOURNAL OF IMMUNOLOGY RESEARCH, 2016, https://doi.org/10.1155/2016/2695396.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028793
Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8+ T-cells are an interesting new player in the field of immunology. Future work should address their exact roles and relative contributions in the immune response against infectious diseases.
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