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dc.contributor.authorRosdah, AA
dc.contributor.authorHolien, JK
dc.contributor.authorDelbridge, LMD
dc.contributor.authorDusting, GJ
dc.contributor.authorLim, SY
dc.date.accessioned2020-12-21T01:49:05Z
dc.date.available2020-12-21T01:49:05Z
dc.date.issued2016-06-01
dc.identifierpii: PRP2235
dc.identifier.citationRosdah, A. A., Holien, J. K., Delbridge, L. M. D., Dusting, G. J. & Lim, S. Y. (2016). Mitochondrial fission - a drug target for cytoprotection or cytodestruction?. PHARMACOLOGY RESEARCH & PERSPECTIVES, 4 (3), https://doi.org/10.1002/prp2.235.
dc.identifier.issn2052-1707
dc.identifier.urihttp://hdl.handle.net/11343/256671
dc.description.abstractMitochondria are morphologically dynamic organelles constantly undergoing processes of fission and fusion that maintain integrity and bioenergetics of the organelle: these processes are vital for cell survival. Disruption in the balance of mitochondrial fusion and fission is thought to play a role in several pathological conditions including ischemic heart disease. Proteins involved in regulating the processes of mitochondrial fusion and fission are therefore potential targets for pharmacological therapies. Mdivi-1 is a small molecule inhibitor of the mitochondrial fission protein Drp1. Inhibiting mitochondrial fission with Mdivi-1 has proven cytoprotective benefits in several cell types involved in a wide array of cardiovascular injury models. On the other hand, Mdivi-1 can also exert antiproliferative and cytotoxic effects, particularly in hyperproliferative cells. In this review, we discuss these divergent effects of Mdivi-1 on cell survival, as well as the potential and limitations of Mdivi-1 as a therapeutic agent.
dc.languageEnglish
dc.publisherJOHN WILEY & SONS LTD
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleMitochondrial fission - a drug target for cytoprotection or cytodestruction?
dc.typeJournal Article
dc.identifier.doi10.1002/prp2.235
melbourne.affiliation.departmentSurgery (St Vincent's)
melbourne.affiliation.departmentPhysiology
melbourne.source.titlePharmacology Research and Perspectives
melbourne.source.volume4
melbourne.source.issue3
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1227653
melbourne.contributor.authorDusting, Gregory
melbourne.contributor.authorDelbridge, Leanne
melbourne.contributor.authorLim, Shiang
dc.identifier.eissn2052-1707
melbourne.accessrightsOpen Access


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