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    Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol

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    Author
    Mooranian, A; Negrulj, R; Chen-Tan, N; Al-Sallami, HS; Fang, Z; Mukkur, TK; Mikov, M; Golocorbin-Kon, S; Fakhoury, M; Watts, GF; ...
    Date
    2016-01-01
    Source Title
    Drug Design, Development and Therapy
    Publisher
    DOVE MEDICAL PRESS LTD
    University of Melbourne Author/s
    Fang, Zhongxiang
    Affiliation
    Agriculture and Food Systems
    Metadata
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    Document Type
    Journal Article
    Citations
    Mooranian, A., Negrulj, R., Chen-Tan, N., Al-Sallami, H. S., Fang, Z., Mukkur, T. K., Mikov, M., Golocorbin-Kon, S., Fakhoury, M., Watts, G. F., Matthews, V., Arfuso, F. & Al-Salami, H. (2016). Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol. DRUG DESIGN DEVELOPMENT AND THERAPY, 10, pp.1221-1230. https://doi.org/10.2147/DDDT.S67349.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256685
    DOI
    10.2147/DDDT.S67349
    Abstract
    INTRODUCTION: In previous studies, we successfully designed complex multicompartmental microcapsules as a platform for the oral targeted delivery of lipophilic drugs in type 2 diabetes (T2D). Probucol (PB) is an antihyperlipidemic and antioxidant drug with the potential to show benefits in T2D. We aimed to create a novel microencapsulated formulation of PB and to examine the shape, size, and chemical, thermal, and rheological properties of these microcapsules in vitro. METHOD: Microencapsulation was carried out using the Büchi-based microencapsulating system developed in our laboratory. Using the polymer, sodium alginate (SA), empty (control, SA) and loaded (test, PB-SA) microcapsules were prepared at a constant ratio (1:30). Complete characterizations of microcapsules, in terms of morphology, thermal profiles, dispersity, and spectral studies, were carried out in triplicate. RESULTS: PB-SA microcapsules displayed uniform and homogeneous characteristics with an average diameter of 1 mm. The microcapsules exhibited pseudoplastic-thixotropic characteristics and showed no chemical interactions between the ingredients. These data were further supported by differential scanning calorimetric analysis and Fourier transform infrared spectral studies, suggesting microcapsule stability. CONCLUSION: The new PB-SA microcapsules have good structural properties and may be suitable for the oral delivery of PB in T2D. Further studies are required to examine the clinical efficacy and safety of PB in T2D.

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